Intracutaneous injections of platelets cause acute pain and protracted hyperalgesia

M. Schmelz, G. Osiander, J. Blunk, M. Ringkamp, P. W. Reeh, H. O. Handwerker

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Suspensions of autologous, washed platelets were intracutaneously injected at the volar forearms of healthy volunteers. Injections of serum and vehicle served as control. Subjects and experimenter were blind with respect to the sequence of injections. In contrast to serum and solvent solution, platelets induced graded burning pain lasting several minutes. Platelet but not serum or vehicle injections dose-dependently caused large axon-reflex flares. At the site of platelet injections an induration developed and in parallel delayed mechanical and heat hyperalgesia was observed. Hyperalgesia to pressure and impact stimulation reached a maximum after 6 h and subsided during the following 48 h. Also, the threshold to heat stimuli decreased moderately by about 1°C, on average, after 24 h. Neither indurations nor hyperalgesia could be detected at the injection sites of serum or vehicle. The pathophysiological significance of this new inflammatory model for the research of posttraumatic hyperalgesia is discussed.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalNeuroscience Letters
Issue number3
StatePublished - May 2 1997
Externally publishedYes


  • hyperalgesia
  • inflammation
  • pain
  • thrombocyte

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Intracutaneous injections of platelets cause acute pain and protracted hyperalgesia'. Together they form a unique fingerprint.

Cite this