Abstract
Three-day-old rat pups with electrodes directed at the medial forebrain bundle at the level of the lateral hypothalamic area were trained to push a paddle to receive electrical brain stimulation. Pups receiving stimulation that was contingent on lifting the paddle responded more frequently than did control pups and also learned a two-choice spatial discrimination task that was rewarded with brain stimulation. The experiments indicate that a neural substrate in the area of the medial forebrain bundle is involved in the central mediation of reinforcement in the rat pup.
Original language | English (US) |
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Pages (from-to) | 1366-1368 |
Number of pages | 3 |
Journal | Science |
Volume | 214 |
Issue number | 4527 |
DOIs | |
State | Published - Jan 1 1981 |
ASJC Scopus subject areas
- General