Intracranial pressure in the cat during nitroglycerin-induced hypotension

M. C. Rogers, C. Hamburger, K. Owen, M. H. Epstein

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Intracranial pressure measurements were made during nitroglycerin-induced hypotension in the cat anesthetized with halothane. A total of 48 individual observations were made in eight animals. The administration of sufficient nitroglycerin to decrease mean arterial pressure from a control value of 87±7 torr by 12±4 torr resulted in an increase in mean intracranial pressure from a control value of 7±2 torr to 12±2 torr. Larger decreases in mean blood pressure were associated with larger increases in intracranial pressure. The increase in intracranial pressure was similar to that previously reported for nitroprusside, and greater as well as more reproducible than that reported for trimethaphan. Thus, nitroglycerin may produce significant increases in intracranial pressure, and this may be a limiting factor in its clinical use.

Original languageEnglish (US)
Pages (from-to)227-229
Number of pages3
Issue number3
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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