Intracranial pressure dose and outcome in traumatic brain injury

Kevin N. Sheth, Deborah M. Stein, Bizhan Aarabi, Peter Hu, Joseph A. Kufera, Thomas M. Scalea, Daniel F. Hanley

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Objective: Detecting and treating elevated intracranial pressure (ICP) is a cornerstone of management in patients with severe traumatic brain injury. The aim of this study was to determine the association between area under the curve measurement of elevated ICP and clinical outcome. Methods: Single center observational study using prospectively collected data at a University hospital, level one-trauma center. Sixty prospective patients with severe traumatic brain injury were prospectively enrolled over a 2-year period. Intracranial pressure measurements were captured using a real-time automated, high resolution vital signs data recording system. Mortality and functional outcome were assessed at 30 days, 3 and 6 months using Extended Glasgow Outcome Scale. Results: Increasing elevated intracranial pressure time dose was associated with mortality (OR 1.08; 95 % confidence interval [CI], 1.01-1.15, p = 0.03) and poor functional outcome at 3 (OR 1.04; CI 1.00-1.07, p = 0.03) and 6 months (1.04; CI 1.01-1.08, p = 0.02). However, there was no association between episodic ICP data and outcome. Conclusions: These results suggest that pressure time dose measurement of intracranial pressure may be used to predict outcome in severe traumatic brain injury and may be a candidate biomarker in this disease.

Original languageEnglish (US)
Pages (from-to)26-32
Number of pages7
JournalNeurocritical care
Issue number1
StatePublished - Feb 2013


  • Critical care
  • Head trauma
  • Intracranial pressure
  • Trauma
  • Traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine


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