TY - GEN
T1 - Intracortical microstimulation of somatosensory cortex generates evoked responses in motor cortex
AU - Osborn, Luke E.
AU - McMullen, David
AU - Christie, Breanne P.
AU - Kudela, Pawel
AU - Thomas, Tessy M.
AU - Thompson, Margaret C.
AU - Nickl, Robert W.
AU - Anaya, Manuel
AU - Srihari, Sahana
AU - Crone, Nathan E.
AU - Wester, Brock A.
AU - Celnik, Pablo A.
AU - Cantarero, Gabriela
AU - Tenore, Francesco V.
AU - Fifer, Matthew S.
N1 - Funding Information:
The authors thank Buz Chmielewski for his helpful discussion, motivation, and dedication that enabled the success of this work. This research was developed with funding from the Defense Advanced Research Projects Agency (DARPA) and the Johns Hopkins University Applied Physics Laboratory (JHU/APL) Postdoctoral Fellowship. The views, opinions and/or findings expressed are those of the author and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government. 1Research & Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory 2National Institute of Mental Health, National Institutes of Health 3Department of Neurosurgery, Johns Hopkins University School of Medicine 4Department of Biomedical Engineering, Johns Hopkins University 5Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine 6Department of Neurology, Johns Hopkins University School of Medicine
Publisher Copyright:
© 2021 IEEE.
PY - 2021/5/4
Y1 - 2021/5/4
N2 - The complex nature of neural connections throughout the cerebral cortex has led to broad interest in understanding cortical functional networks of tactile perception and sensorimotor integration. Cortico-cortical evoked potentials (CCEPs) can be used as physiological markers to study and map cerebral networks in the brain. In a human participant with bi-hemispheric microelectrode array implants in sensorimotor regions of the brain, we found that intracortical microstimulation (ICMS) of the primary somatosensory cortex can lead to evoked responses in the motor cortex in the same hemisphere, indicating connectivity between these sensorimotor regions. Single ICMS pulses were not consciously perceived, but elicited a rapid evoked potential approximately 20 ms after stimulus onset. Multi-pulse ICMS trains, perceived as tactile sensations in the thumb, sustained over an approximately 33 ms period, led to a delayed evoked response roughly 80 ms after stimulus onset. This work is important not only for better understanding the functional relationship between cortical areas, specifically somatosensory and motor cortices, but also to provide insight on pathways where neuromodulation techniques could be employed for rehabilitation or mitigation of sensorimotor neurodegenerative effects.
AB - The complex nature of neural connections throughout the cerebral cortex has led to broad interest in understanding cortical functional networks of tactile perception and sensorimotor integration. Cortico-cortical evoked potentials (CCEPs) can be used as physiological markers to study and map cerebral networks in the brain. In a human participant with bi-hemispheric microelectrode array implants in sensorimotor regions of the brain, we found that intracortical microstimulation (ICMS) of the primary somatosensory cortex can lead to evoked responses in the motor cortex in the same hemisphere, indicating connectivity between these sensorimotor regions. Single ICMS pulses were not consciously perceived, but elicited a rapid evoked potential approximately 20 ms after stimulus onset. Multi-pulse ICMS trains, perceived as tactile sensations in the thumb, sustained over an approximately 33 ms period, led to a delayed evoked response roughly 80 ms after stimulus onset. This work is important not only for better understanding the functional relationship between cortical areas, specifically somatosensory and motor cortices, but also to provide insight on pathways where neuromodulation techniques could be employed for rehabilitation or mitigation of sensorimotor neurodegenerative effects.
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U2 - 10.1109/NER49283.2021.9441123
DO - 10.1109/NER49283.2021.9441123
M3 - Conference contribution
AN - SCOPUS:85107509664
T3 - International IEEE/EMBS Conference on Neural Engineering, NER
SP - 53
EP - 56
BT - 2021 10th International IEEE/EMBS Conference on Neural Engineering, NER 2021
PB - IEEE Computer Society
T2 - 10th International IEEE/EMBS Conference on Neural Engineering, NER 2021
Y2 - 4 May 2021 through 6 May 2021
ER -