TY - JOUR
T1 - Intracellular α2C-Adrenoceptors
T2 - Storage depot, stunted development or signaling domain?
AU - Chotani, Maqsood A.
AU - Flavahan, Nicholas A.
N1 - Funding Information:
This study was supported in part by grants from the NIH/National Heart, Lung, and Blood Institute ( R21HL088087, MAC ; R01HL080119, NAF ) and the American Heart Association Great Rivers Affiliate (Beginning Grant-in-Aid, 0765204B, MAC ).
PY - 2011/8
Y1 - 2011/8
N2 - G-protein coupled receptors (GPCRs) are generally considered to function as cell surface signaling structures that respond to extracellular mediators, many of which do not readily access the cell's interior. Indeed, most GPCRs are preferentially targeted to the plasma membrane. However, some receptors, including α2C-Adrenoceptors, challenge conventional concepts of GPCR activity by being preferentially retained and localized within intracellular organelles. This review will address the issues associated with this unusual GPCR localization and discuss whether it represents a novel sub-cellular niche for GPCR signaling, whether these receptors are being stored for rapid deployment to the cell surface, or whether they represent immature or incomplete receptor systems.
AB - G-protein coupled receptors (GPCRs) are generally considered to function as cell surface signaling structures that respond to extracellular mediators, many of which do not readily access the cell's interior. Indeed, most GPCRs are preferentially targeted to the plasma membrane. However, some receptors, including α2C-Adrenoceptors, challenge conventional concepts of GPCR activity by being preferentially retained and localized within intracellular organelles. This review will address the issues associated with this unusual GPCR localization and discuss whether it represents a novel sub-cellular niche for GPCR signaling, whether these receptors are being stored for rapid deployment to the cell surface, or whether they represent immature or incomplete receptor systems.
KW - Cold
KW - Endoplasmic Reticulum
KW - Golgi
KW - Signal transduction
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U2 - 10.1016/j.bbamcr.2011.05.006
DO - 10.1016/j.bbamcr.2011.05.006
M3 - Review article
C2 - 21605601
AN - SCOPUS:79959358168
SN - 0167-4889
VL - 1813
SP - 1495
EP - 1503
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
IS - 8
ER -