Intracellular Signaling: Mediators and Protective Responses

John W. Thompson; Jinchong Xu; Valina L. Dawson; Miguel A. Perez-Pinzon; Ted Dawson

doi:10.1016/B978-0-323-69424-7.00006-5

Intracellular Signaling: Mediators and Protective Responses

John W. Thompson, Jinchong Xu, Valina L. Dawson, Miguel A. Perez-Pinzon, Ted Dawson

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

In this chapter, we review preconditioning, which is an adaptive response to a noxious but nonlethal experience that activates an intracellular reaction rendering the tissue tolerant to a subsequent potentially lethal event. Harnessing the power of preconditioning and tolerance has promise as a new arena to develop novel therapies to protect the nervous system from ischemic injury.

Original language	English (US)
Title of host publication	Stroke
Subtitle of host publication	Pathophysiology, Diagnosis, and Management
Publisher	Elsevier
Pages	74 and 81.e5
ISBN (Electronic)	9780323694247
DOIs	https://doi.org/10.1016/B978-0-323-69424-7.00006-5
State	Published - Jan 1 2021

Keywords

Cross-tolerance
Neuroprotection
Plasticity
Preconditioning
Tolerance

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-323-69424-7.00006-5

Cite this

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abstract = "In this chapter, we review preconditioning, which is an adaptive response to a noxious but nonlethal experience that activates an intracellular reaction rendering the tissue tolerant to a subsequent potentially lethal event. Harnessing the power of preconditioning and tolerance has promise as a new arena to develop novel therapies to protect the nervous system from ischemic injury.",

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AU - Dawson, Ted

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AB - In this chapter, we review preconditioning, which is an adaptive response to a noxious but nonlethal experience that activates an intracellular reaction rendering the tissue tolerant to a subsequent potentially lethal event. Harnessing the power of preconditioning and tolerance has promise as a new arena to develop novel therapies to protect the nervous system from ischemic injury.

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KW - Plasticity

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KW - Tolerance

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ER -

Intracellular Signaling: Mediators and Protective Responses

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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