Abstract
The stretch of adult papillary muscle elicits a chain of autocrine/paracrine events in which the Na+/H+ exchanger (NHE-1) activation is the central step. This activation is induced by a sequential angiotensin II-endothelin (Ang II-ET) release and results in an increase in intracellular Na+ (Nai +) without significant changes in intracellular pH. The increase in Nai + negatively shifts the reverse potential of the Na +/Ca2+ exchanger (NCX) thus inducing cell Ca2+ influx that augments myocardial contractility. This increase in force represents the mechanical counterpart of the autocrine/paracrine mechanism triggered by stretch and has been called the slow force response (SFR) to stretch.
Original language | English (US) |
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Pages (from-to) | 211-220 |
Number of pages | 10 |
Journal | Regulatory Peptides |
Volume | 128 |
Issue number | 3 |
DOIs | |
State | Published - Jun 30 2005 |
Keywords
- Angiotensin II
- Endothelin
- Na /Ca exchanger
- Na/H exchanger
ASJC Scopus subject areas
- Biochemistry
- Physiology
- Endocrinology
- Clinical Biochemistry
- Cellular and Molecular Neuroscience