Intracellular signaling following myocardial stretch: An autocrine/paracrine loop

Horacio E. Cingolani, Néstor G. Pérez, Ernesto A. Aiello, María C. Camilión De Hurtado

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


The stretch of adult papillary muscle elicits a chain of autocrine/paracrine events in which the Na+/H+ exchanger (NHE-1) activation is the central step. This activation is induced by a sequential angiotensin II-endothelin (Ang II-ET) release and results in an increase in intracellular Na+ (Nai +) without significant changes in intracellular pH. The increase in Nai + negatively shifts the reverse potential of the Na +/Ca2+ exchanger (NCX) thus inducing cell Ca2+ influx that augments myocardial contractility. This increase in force represents the mechanical counterpart of the autocrine/paracrine mechanism triggered by stretch and has been called the slow force response (SFR) to stretch.

Original languageEnglish (US)
Pages (from-to)211-220
Number of pages10
JournalRegulatory Peptides
Issue number3
StatePublished - Jun 30 2005


  • Angiotensin II
  • Endothelin
  • Na /Ca exchanger
  • Na/H exchanger

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience


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