Intracellular nanoparticle coating stability determines nanoparticle diagnostics efficacy and cell functionality

Stefaan J.H. Soenen; Uwe Himmelreich; Nele Nuytten; Thomas R. Pisanic; Aldo Ferrari; Marcel De Cuyper

doi:10.1002/smll.201000763

Intracellular nanoparticle coating stability determines nanoparticle diagnostics efficacy and cell functionality

Stefaan J.H. Soenen
, Uwe Himmelreich
, Nele Nuytten
, Thomas R. Pisanic
, Aldo Ferrari
, Marcel De Cuyper

Research output: Contribution to journal › Article › peer-review

Abstract

Intracellular nanoparticle degradation affects cell functionality and inhibits MR signals. Four commonly used iron oxide nanoparticles show clear pH-dependent degradation, the extent of which is governed by the nature of the coating material. Lipid-coated particles provide the best resistance and display extensive intracellular clustering, which enhances MR contrast and increases the durability of the label.

Original language	English (US)
Pages (from-to)	2136-2145
Number of pages	10
Journal	Small
Volume	6
Issue number	19
DOIs	https://doi.org/10.1002/smll.201000763
State	Published - 2010
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
General Chemistry
Biomaterials
General Materials Science
Engineering (miscellaneous)

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10.1002/smll.201000763

Cite this

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title = "Intracellular nanoparticle coating stability determines nanoparticle diagnostics efficacy and cell functionality",

abstract = "Intracellular nanoparticle degradation affects cell functionality and inhibits MR signals. Four commonly used iron oxide nanoparticles show clear pH-dependent degradation, the extent of which is governed by the nature of the coating material. Lipid-coated particles provide the best resistance and display extensive intracellular clustering, which enhances MR contrast and increases the durability of the label.",

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AU - Soenen, Stefaan J.H.

AU - Himmelreich, Uwe

AU - Nuytten, Nele

AU - Pisanic, Thomas R.

AU - Ferrari, Aldo

AU - De Cuyper, Marcel

PY - 2010

Y1 - 2010

N2 - Intracellular nanoparticle degradation affects cell functionality and inhibits MR signals. Four commonly used iron oxide nanoparticles show clear pH-dependent degradation, the extent of which is governed by the nature of the coating material. Lipid-coated particles provide the best resistance and display extensive intracellular clustering, which enhances MR contrast and increases the durability of the label.

AB - Intracellular nanoparticle degradation affects cell functionality and inhibits MR signals. Four commonly used iron oxide nanoparticles show clear pH-dependent degradation, the extent of which is governed by the nature of the coating material. Lipid-coated particles provide the best resistance and display extensive intracellular clustering, which enhances MR contrast and increases the durability of the label.

UR - https://www.scopus.com/pages/publications/77957192163

UR - https://www.scopus.com/pages/publications/77957192163#tab=citedBy

U2 - 10.1002/smll.201000763

DO - 10.1002/smll.201000763

M3 - Article

C2 - 20818621

AN - SCOPUS:77957192163

SN - 1613-6810

VL - 6

SP - 2136

EP - 2145

JO - Small

JF - Small

IS - 19

ER -

Intracellular nanoparticle coating stability determines nanoparticle diagnostics efficacy and cell functionality

Abstract

ASJC Scopus subject areas

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