Intracellular hydrogelation of small molecules inhibits bacterial growth

Zhimou Yang; Gaolin Liang; Zufeng Guo; Zhihong Guo; Bing Xu

doi:10.1002/anie.200701697

Intracellular hydrogelation of small molecules inhibits bacterial growth

Zhimou Yang, Gaolin Liang, Zufeng Guo, Zhihong Guo, Bing Xu

Research output: Contribution to journal › Article › peer-review

166 Scopus citations

Abstract

(Figure Presented) Control from within: Supramolecular hydrogelation to form nanostructures intracellularly (see picture) has been developed as a new methodology to control the fate of cells. Enzyme-regulated self-assembly of small molecules inside cells could lead to a new paradigm for managing cellular processes, understanding cellular functions, and developing new therapeutics through supramolecular chemistry.

Original language	English (US)
Pages (from-to)	8216-8219
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	43
DOIs	https://doi.org/10.1002/anie.200701697
State	Published - 2007
Externally published	Yes

Keywords

Enzymes
Hydrogelation
Hydrolysis
Inhibitors
Self-assembly

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.200701697

Cite this

@article{61a21b34a9ff49ccab5be0c6fc4e1048,

title = "Intracellular hydrogelation of small molecules inhibits bacterial growth",

abstract = "(Figure Presented) Control from within: Supramolecular hydrogelation to form nanostructures intracellularly (see picture) has been developed as a new methodology to control the fate of cells. Enzyme-regulated self-assembly of small molecules inside cells could lead to a new paradigm for managing cellular processes, understanding cellular functions, and developing new therapeutics through supramolecular chemistry.",

keywords = "Enzymes, Hydrogelation, Hydrolysis, Inhibitors, Self-assembly",

author = "Zhimou Yang and Gaolin Liang and Zufeng Guo and Zhihong Guo and Bing Xu",

year = "2007",

doi = "10.1002/anie.200701697",

language = "English (US)",

volume = "46",

pages = "8216--8219",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "43",

}

TY - JOUR

T1 - Intracellular hydrogelation of small molecules inhibits bacterial growth

AU - Yang, Zhimou

AU - Liang, Gaolin

AU - Guo, Zufeng

AU - Guo, Zhihong

AU - Xu, Bing

PY - 2007

Y1 - 2007

N2 - (Figure Presented) Control from within: Supramolecular hydrogelation to form nanostructures intracellularly (see picture) has been developed as a new methodology to control the fate of cells. Enzyme-regulated self-assembly of small molecules inside cells could lead to a new paradigm for managing cellular processes, understanding cellular functions, and developing new therapeutics through supramolecular chemistry.

AB - (Figure Presented) Control from within: Supramolecular hydrogelation to form nanostructures intracellularly (see picture) has been developed as a new methodology to control the fate of cells. Enzyme-regulated self-assembly of small molecules inside cells could lead to a new paradigm for managing cellular processes, understanding cellular functions, and developing new therapeutics through supramolecular chemistry.

KW - Enzymes

KW - Hydrogelation

KW - Hydrolysis

KW - Inhibitors

KW - Self-assembly

UR - http://www.scopus.com/inward/record.url?scp=36049033046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36049033046&partnerID=8YFLogxK

U2 - 10.1002/anie.200701697

DO - 10.1002/anie.200701697

M3 - Article

C2 - 17705321

AN - SCOPUS:36049033046

SN - 1433-7851

VL - 46

SP - 8216

EP - 8219

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 43

ER -

Intracellular hydrogelation of small molecules inhibits bacterial growth

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this