Intracellular hydrogelation of small molecules inhibits bacterial growth

Zhimou Yang, Gaolin Liang, Zufeng Guo, Zhihong Guo, Bing Xu

Research output: Contribution to journalArticlepeer-review

166 Scopus citations


(Figure Presented) Control from within: Supramolecular hydrogelation to form nanostructures intracellularly (see picture) has been developed as a new methodology to control the fate of cells. Enzyme-regulated self-assembly of small molecules inside cells could lead to a new paradigm for managing cellular processes, understanding cellular functions, and developing new therapeutics through supramolecular chemistry.

Original languageEnglish (US)
Pages (from-to)8216-8219
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number43
StatePublished - 2007
Externally publishedYes


  • Enzymes
  • Hydrogelation
  • Hydrolysis
  • Inhibitors
  • Self-assembly

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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