Abstract
Heterotopic cardiac xenotransplantation in the intra-abdominal position has been studied extensively in a pig-to-baboon model to define the optimal donor genetics and immunosuppressive regimen to prevent xenograft rejection. Extensive investigation using this model is a necessary stepping stone toward the development of a life-supporting animal model, with the ultimate goal of demonstrating suitability for clinical cardiac xenotransplantation trials. Aspects of surgical technique, pre- and post-operative care, graft monitoring, and minimization of infectious risk have all required refinement and optimization of heterotopic cardiac xenotransplantation over time. This review details non-immunologic obstacles relevant to this model described by our group and in the literature, as well as strategies that have been developed to address these specific challenges.
Original language | English (US) |
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Article number | 95 |
Journal | Frontiers in Cardiovascular Medicine |
Volume | 6 |
DOIs | |
State | Published - Jul 25 2019 |
Externally published | Yes |
Keywords
- abdominal
- baboon
- cardiac
- complications
- heterotopic
- pig
- xenograft
- xenotransplant
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine