Intestinal microbiota-produced trimethylamine-N-oxide and its association with coronary stenosis and HIV serostatus

P. Elliott Miller; Sabina A. Haberlen; Todd T. Brown; Joseph B. Margolick; Joseph A. DiDonato; Stanley L. Hazen; Mallory D. Witt; Lawrence A. Kingsley; Frank J. Palella; Matthew Budoff; Lisa P. Jacobson; Wendy S. Post; Cynthia L. Sears

doi:10.1097/QAI.0000000000000937

Intestinal microbiota-produced trimethylamine-N-oxide and its association with coronary stenosis and HIV serostatus

P. Elliott Miller, Sabina A. Haberlen, Todd T. Brown, Joseph B. Margolick, Joseph A. DiDonato, Stanley L. Hazen, Mallory D. Witt, Lawrence A. Kingsley, Frank J. Palella, Matthew Budoff, Lisa P. Jacobson, Wendy S. Post, Cynthia L. Sears

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18 Scopus citations

Abstract

Recent evidence has shown a complex relationship between the gut microbiota, dietary nutrients, and cardiovascular disease (CVD). Trimethylamine-N-oxide (TMAO) production, initiated by the microbiota, has been associated with CVD events. We sought to test if this association exists in HIV-infected persons. After adjusting for aspirin use and CVD risk factors, HIV-infected men were more likely to have coronary stenosis in the second and third TMAO quartiles compared with the first quartile, but did not differ significantly in the fourth quartile. We found an inverted U-shaped association between TMAO levels and the presence of coronary artery stenosis among HIV-infected men.

Original language	English (US)
Pages (from-to)	114-118
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	72
Issue number	1
DOIs	https://doi.org/10.1097/QAI.0000000000000937
State	Published - May 1 2016

Keywords

Coronary artery disease
HIV
Trimethylamine-N-oxide

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

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10.1097/QAI.0000000000000937

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Elliott Miller, P., Haberlen, S. A., Brown, T. T., Margolick, J. B., DiDonato, J. A., Hazen, S. L., Witt, M. D., Kingsley, L. A., Palella, F. J., Budoff, M., Jacobson, L. P., Post, W. S., & Sears, C. L. (2016). Intestinal microbiota-produced trimethylamine-N-oxide and its association with coronary stenosis and HIV serostatus. Journal of Acquired Immune Deficiency Syndromes, 72(1), 114-118. https://doi.org/10.1097/QAI.0000000000000937

Elliott Miller, P, Haberlen, SA , Brown, TT , Margolick, JB, DiDonato, JA, Hazen, SL, Witt, MD, Kingsley, LA, Palella, FJ, Budoff, M, Jacobson, LP , Post, WS & Sears, CL 2016, 'Intestinal microbiota-produced trimethylamine-N-oxide and its association with coronary stenosis and HIV serostatus', Journal of Acquired Immune Deficiency Syndromes, vol. 72, no. 1, pp. 114-118. https://doi.org/10.1097/QAI.0000000000000937

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abstract = "Recent evidence has shown a complex relationship between the gut microbiota, dietary nutrients, and cardiovascular disease (CVD). Trimethylamine-N-oxide (TMAO) production, initiated by the microbiota, has been associated with CVD events. We sought to test if this association exists in HIV-infected persons. After adjusting for aspirin use and CVD risk factors, HIV-infected men were more likely to have coronary stenosis in the second and third TMAO quartiles compared with the first quartile, but did not differ significantly in the fourth quartile. We found an inverted U-shaped association between TMAO levels and the presence of coronary artery stenosis among HIV-infected men.",

keywords = "Coronary artery disease, HIV, Trimethylamine-N-oxide",

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AU - Margolick, Joseph B.

AU - DiDonato, Joseph A.

AU - Hazen, Stanley L.

AU - Witt, Mallory D.

AU - Kingsley, Lawrence A.

AU - Palella, Frank J.

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AU - Jacobson, Lisa P.

AU - Post, Wendy S.

AU - Sears, Cynthia L.

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AB - Recent evidence has shown a complex relationship between the gut microbiota, dietary nutrients, and cardiovascular disease (CVD). Trimethylamine-N-oxide (TMAO) production, initiated by the microbiota, has been associated with CVD events. We sought to test if this association exists in HIV-infected persons. After adjusting for aspirin use and CVD risk factors, HIV-infected men were more likely to have coronary stenosis in the second and third TMAO quartiles compared with the first quartile, but did not differ significantly in the fourth quartile. We found an inverted U-shaped association between TMAO levels and the presence of coronary artery stenosis among HIV-infected men.

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Intestinal microbiota-produced trimethylamine-N-oxide and its association with coronary stenosis and HIV serostatus

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