TY - JOUR
T1 - Intestinal microbiota-kidney cross talk in acute kidney injury and chronic kidney disease
AU - Noel, Sanjeev
AU - Martina-Lingua, Maria N.
AU - Bandapalle, Samatha
AU - Pluznick, Jennifer
AU - Hamad, Abdel Rahim A.
AU - Peterson, Daniel A.
AU - Rabb, Hamid
N1 - Publisher Copyright:
© 2014 S. Karger AG, Basel.
PY - 2014/4/16
Y1 - 2014/4/16
N2 - The pathophysiology of acute kidney injury (AKI) involves multiple and overlapping immunological, biochemical, and hemodynamic mechanisms that modulate the effects of both the initial insult and the subsequent repair. Limited but recent experimental data have revealed that the intestinal microbiota significantly affects outcomes in AKI. Additional evidence shows significant changes in the intestinal microbiota in chronic kidney disease patients and in experimental AKI. In this minireview, we discuss the current status of the effect of intestinal microbiota on kidney diseases, the immunomodulatory effects of intestinal microbiota, and the potential mechanisms by which microbiota can modify kidney diseases and vice versa. We also propose future studies to clarify the role of intestinal microbiota in kidney diseases and to explore how the modification of gut microbiota may be a potential therapeutic tool.
AB - The pathophysiology of acute kidney injury (AKI) involves multiple and overlapping immunological, biochemical, and hemodynamic mechanisms that modulate the effects of both the initial insult and the subsequent repair. Limited but recent experimental data have revealed that the intestinal microbiota significantly affects outcomes in AKI. Additional evidence shows significant changes in the intestinal microbiota in chronic kidney disease patients and in experimental AKI. In this minireview, we discuss the current status of the effect of intestinal microbiota on kidney diseases, the immunomodulatory effects of intestinal microbiota, and the potential mechanisms by which microbiota can modify kidney diseases and vice versa. We also propose future studies to clarify the role of intestinal microbiota in kidney diseases and to explore how the modification of gut microbiota may be a potential therapeutic tool.
KW - Acute kidney injury
KW - Chronic kidney disease
KW - Gut
KW - Intestinal microbiota
UR - http://www.scopus.com/inward/record.url?scp=84927737610&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84927737610&partnerID=8YFLogxK
U2 - 10.1159/000363209
DO - 10.1159/000363209
M3 - Article
C2 - 25343838
AN - SCOPUS:84927737610
SN - 1660-2110
VL - 127
SP - 139
EP - 143
JO - Nephron - Clinical Practice
JF - Nephron - Clinical Practice
IS - 1-4
ER -