Interventions for human frailty: Physical activity as a model

Linda P. Fried

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


In the last 100 years, populations in developed countries have experienced an unprecedented addition of 30 years to life expectancy. Developing countries are now experiencing this same phenomenon, but over a shorter time frame. With this success comes the challenge of maximizing health and vitality across these added years. The compression of morbidity to the latest point in the human life span could unleash a sustained third demographic dividend that benefits all of society. To accomplish this, society needs to invest in the prevention and treatment of frailty, as well as in the prevention of chronic diseases at every age and stage of life. A model intervention, physical activity, may offer a road map.

Original languageEnglish (US)
Article numbera025916
JournalCold Spring Harbor Perspectives in Medicine
Issue number6
StatePublished - Jun 2016

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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