TY - JOUR
T1 - Interval bone mineral density with long-term gonadotropin-releasing hormone agonist suppression
AU - Damewood, M. D.
AU - Schlaff, W. D.
AU - Hesla, J. S.
AU - Rock, J. A.
PY - 1989
Y1 - 1989
N2 - Twenty-six patients of mean age 37 ± 4.8 (SD) years, who received a 6-month course of gonadotropin-releasing hormone (GnRH) analogue, were selected for study. Bone mineral density (BMD) was measured by dual-photon absorptiometry before initiation and after completion of agonist therapy. Mean BMD (g/cm2) by dual-photon absorptiometry at L2 to L4, femoral neck, Ward's triangle, and the trochanteric area did not change significantly (P = not significant [NS]) after 6 months of GnRH analogue suppression. Mean percent (%) expected density as standardized for age, weight, and sex remained in the range of 89.3% to 94.2% (P = NS). The interval detectable change in BMD after therapy was 0.05 ± 0.06 g/cm2. These findings are reassuring with respect to the use of long-term GnRH analogue regimens to induce a hypoestrogenic state in the treatment of hormone-dependent conditions.
AB - Twenty-six patients of mean age 37 ± 4.8 (SD) years, who received a 6-month course of gonadotropin-releasing hormone (GnRH) analogue, were selected for study. Bone mineral density (BMD) was measured by dual-photon absorptiometry before initiation and after completion of agonist therapy. Mean BMD (g/cm2) by dual-photon absorptiometry at L2 to L4, femoral neck, Ward's triangle, and the trochanteric area did not change significantly (P = not significant [NS]) after 6 months of GnRH analogue suppression. Mean percent (%) expected density as standardized for age, weight, and sex remained in the range of 89.3% to 94.2% (P = NS). The interval detectable change in BMD after therapy was 0.05 ± 0.06 g/cm2. These findings are reassuring with respect to the use of long-term GnRH analogue regimens to induce a hypoestrogenic state in the treatment of hormone-dependent conditions.
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U2 - 10.1016/S0015-0282(16)60970-6
DO - 10.1016/S0015-0282(16)60970-6
M3 - Article
C2 - 2680617
AN - SCOPUS:0024429497
SN - 0015-0282
VL - 52
SP - 596
EP - 599
JO - Fertility and sterility
JF - Fertility and sterility
IS - 4
ER -