@article{9bd69d474529413e8a7d5d0aaa39ec61,
title = "Interspecies differences in tenofovir alafenamide fumarate stability in plasma",
abstract = "Tenofovir (TFV) alafenamide fumarate (TAF) is an antiretroviral that has been evaluated in alternative drug delivery systems in several species. The ex vivo stability of TAF was evaluated, and TAF was stable in dog-, sheep-, and macaque-spiked plasma. A negative bias was observed in TAF recovery in rabbit-spiked plasma; there was complete loss of TAF and corresponding overestimation of TFV in rodent-spiked plasma. These data highlight considerations when evaluating TAF and TFV concentrations in preclinical studies.",
keywords = "HIV, Hydrolysis, Pharmacology, TAF, Tenofovir alafenamide fumarate",
author = "Parsons, {Teresa L.} and Gwenden, {Kevin N.} and Marzinke, {Mark A.}",
note = "Funding Information: TAF was acquired through a material transfer agreement with Gilead Sciences. This study was supported in part by the U.S. National Institutes of Health (NIH), including the National Institute of Allergy and Infectious Diseases (NIAID) under the program project grant U19AI113127, as well as the Johns Hopkins University Center for AIDS Research, an NIH-funded program (P30AI094189), which is supported by the following NIH Co-Funding and Participating Institutes and Centers: NIAID, NCI, NICHD, NHLBI, NIDA, NIMH, NIA, FIC, and OAR. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Funding Information: This study was supported in part by the U.S. National Institutes of Health (NIH), including the National Institute of Allergy and Infectious Diseases (NIAID) under the program project grant U19AI113127, as well as the Johns Hopkins University Center for AIDS Research, an NIH-funded program (P30AI094189), which is supported by the following NIH Co-Funding and Participating Institutes and Centers: NIAID, NCI, NICHD, NHLBI, NIDA, NIMH, NIA, FIC, and OAR. Publisher Copyright: Copyright {\textcopyright} 2020 American Society for Microbiology. All Rights Reserved.",
year = "2020",
month = sep,
doi = "10.1128/AAC.00930-20",
language = "English (US)",
volume = "64",
journal = "Antimicrobial agents and chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "9",
}