Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia

Reggie H. Lee; Alexandre Couto e Silva; Francesca M. Lerner; Carl S. Wilkins; Stephen E. Valido; Daniel D. Klein; Celeste Y. Wu; Jake T. Neumann; David Della-Morte; Stephen H. Koslow; Alireza Minagar; Hung Wen Lin

doi:10.1152/ajpheart.00482.2016

Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia

Reggie H. Lee, Alexandre Couto e Silva, Francesca M. Lerner, Carl S. Wilkins, Stephen E. Valido, Daniel D. Klein, Celeste Y. Wu, Jake T. Neumann, David Della-Morte, Stephen H. Koslow, Alireza Minagar, Hung Wen Lin

Research output: Contribution to journal › Article › peer-review

Abstract

Sympathetic nervous system activity is increased after cardiopulmonary arrest, resulting in vasoconstrictor release from the perivascular sympathetic nerves of cerebral arteries. However, the pathophysiological function of the perivascular sympathetic nerves in the ischemic brain remains unclear. A rat model of global cerebral ischemia (asphyxial cardiac arrest, ACA) was used to investigate perivascular sympathetic nerves of cerebral arteries via bilateral decentralization (preganglionic lesion) of the superior cervical ganglion (SCG). Decentralization of the SCG 5 days before ACA alleviated hypoperfusion and afforded hippocampal neuroprotection and improved functional outcomes. These studies can provide further insights into the functional mechanism (s) of the sympathetic nervous system during ischemia. NEW & NOTEWORTHY Interruption of the perivascular sympathetic nerves can alleviate CA-induced hypoperfusion and neuronal cell death in the CA1 region of the hippocampus to enhance functional learning and memory.

Original language	English (US)
Pages (from-to)	H182-H188
Journal	American Journal of Physiology - Heart and Circulatory Physiology
Volume	312
Issue number	1
DOIs	https://doi.org/10.1152/ajpheart.00482.2016
State	Published - 2017
Externally published	Yes

Keywords

Behavior (rodent)
Brain ischemia
Cardiac arrest
Cerebral blood flow
Cerebral blood flow measurement
Cognitive impairment
Global ischemia
Neuroprotection
Pial vessels
Sympathetic nervous system
Two photon microscopy

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

Access to Document

10.1152/ajpheart.00482.2016

Cite this

Lee, R. H., Couto e Silva, A., Lerner, F. M., Wilkins, C. S., Valido, S. E., Klein, D. D., Wu, C. Y., Neumann, J. T., Della-Morte, D., Koslow, S. H., Minagar, A., & Lin, H. W. (2017). Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia. American Journal of Physiology - Heart and Circulatory Physiology, 312(1), H182-H188. https://doi.org/10.1152/ajpheart.00482.2016

Lee, RH, Couto e Silva, A, Lerner, FM, Wilkins, CS, Valido, SE, Klein, DD, Wu, CY, Neumann, JT, Della-Morte, D, Koslow, SH, Minagar, A & Lin, HW 2017, 'Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia', American Journal of Physiology - Heart and Circulatory Physiology, vol. 312, no. 1, pp. H182-H188. https://doi.org/10.1152/ajpheart.00482.2016

@article{c6384ee14dab4738a52e51362f7a00a3,

title = "Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia",

abstract = "Sympathetic nervous system activity is increased after cardiopulmonary arrest, resulting in vasoconstrictor release from the perivascular sympathetic nerves of cerebral arteries. However, the pathophysiological function of the perivascular sympathetic nerves in the ischemic brain remains unclear. A rat model of global cerebral ischemia (asphyxial cardiac arrest, ACA) was used to investigate perivascular sympathetic nerves of cerebral arteries via bilateral decentralization (preganglionic lesion) of the superior cervical ganglion (SCG). Decentralization of the SCG 5 days before ACA alleviated hypoperfusion and afforded hippocampal neuroprotection and improved functional outcomes. These studies can provide further insights into the functional mechanism (s) of the sympathetic nervous system during ischemia. NEW & NOTEWORTHY Interruption of the perivascular sympathetic nerves can alleviate CA-induced hypoperfusion and neuronal cell death in the CA1 region of the hippocampus to enhance functional learning and memory.",

keywords = "Behavior (rodent), Brain ischemia, Cardiac arrest, Cerebral blood flow, Cerebral blood flow measurement, Cognitive impairment, Global ischemia, Neuroprotection, Pial vessels, Sympathetic nervous system, Two photon microscopy",

author = "Lee, {Reggie H.} and {Couto e Silva}, Alexandre and Lerner, {Francesca M.} and Wilkins, {Carl S.} and Valido, {Stephen E.} and Klein, {Daniel D.} and Wu, {Celeste Y.} and Neumann, {Jake T.} and David Della-Morte and Koslow, {Stephen H.} and Alireza Minagar and Lin, {Hung Wen}",

note = "Publisher Copyright: {\textcopyright} 2017 the American Physiological Society.",

year = "2017",

doi = "10.1152/ajpheart.00482.2016",

language = "English (US)",

volume = "312",

pages = "H182--H188",

journal = "American Journal of Physiology - Heart and Circulatory Physiology",

issn = "0363-6135",

publisher = "American Physiological Society",

number = "1",

}

TY - JOUR

T1 - Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia

AU - Lee, Reggie H.

AU - Couto e Silva, Alexandre

AU - Lerner, Francesca M.

AU - Wilkins, Carl S.

AU - Valido, Stephen E.

AU - Klein, Daniel D.

AU - Wu, Celeste Y.

AU - Neumann, Jake T.

AU - Della-Morte, David

AU - Koslow, Stephen H.

AU - Minagar, Alireza

AU - Lin, Hung Wen

PY - 2017

Y1 - 2017

N2 - Sympathetic nervous system activity is increased after cardiopulmonary arrest, resulting in vasoconstrictor release from the perivascular sympathetic nerves of cerebral arteries. However, the pathophysiological function of the perivascular sympathetic nerves in the ischemic brain remains unclear. A rat model of global cerebral ischemia (asphyxial cardiac arrest, ACA) was used to investigate perivascular sympathetic nerves of cerebral arteries via bilateral decentralization (preganglionic lesion) of the superior cervical ganglion (SCG). Decentralization of the SCG 5 days before ACA alleviated hypoperfusion and afforded hippocampal neuroprotection and improved functional outcomes. These studies can provide further insights into the functional mechanism (s) of the sympathetic nervous system during ischemia. NEW & NOTEWORTHY Interruption of the perivascular sympathetic nerves can alleviate CA-induced hypoperfusion and neuronal cell death in the CA1 region of the hippocampus to enhance functional learning and memory.

AB - Sympathetic nervous system activity is increased after cardiopulmonary arrest, resulting in vasoconstrictor release from the perivascular sympathetic nerves of cerebral arteries. However, the pathophysiological function of the perivascular sympathetic nerves in the ischemic brain remains unclear. A rat model of global cerebral ischemia (asphyxial cardiac arrest, ACA) was used to investigate perivascular sympathetic nerves of cerebral arteries via bilateral decentralization (preganglionic lesion) of the superior cervical ganglion (SCG). Decentralization of the SCG 5 days before ACA alleviated hypoperfusion and afforded hippocampal neuroprotection and improved functional outcomes. These studies can provide further insights into the functional mechanism (s) of the sympathetic nervous system during ischemia. NEW & NOTEWORTHY Interruption of the perivascular sympathetic nerves can alleviate CA-induced hypoperfusion and neuronal cell death in the CA1 region of the hippocampus to enhance functional learning and memory.

KW - Behavior (rodent)

KW - Brain ischemia

KW - Cardiac arrest

KW - Cerebral blood flow

KW - Cerebral blood flow measurement

KW - Cognitive impairment

KW - Global ischemia

KW - Neuroprotection

KW - Pial vessels

KW - Sympathetic nervous system

KW - Two photon microscopy

UR - http://www.scopus.com/inward/record.url?scp=85008315309&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85008315309&partnerID=8YFLogxK

U2 - 10.1152/ajpheart.00482.2016

DO - 10.1152/ajpheart.00482.2016

M3 - Article

C2 - 27864234

AN - SCOPUS:85008315309

SN - 0363-6135

VL - 312

SP - H182-H188

JO - American Journal of Physiology - Heart and Circulatory Physiology

JF - American Journal of Physiology - Heart and Circulatory Physiology

IS - 1

ER -

Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this