Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia

Reggie H. Lee; Alexandre Couto e Silva; Francesca M. Lerner; Carl S. Wilkins; Stephen E. Valido; Daniel D. Klein; Celeste Y. Wu; Jake T. Neumann; David Della-Morte; Stephen H. Koslow; Alireza Minagar; Hung Wen Lin

doi:10.1152/ajpheart.00482.2016

Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia

Reggie H. Lee, Alexandre Couto e Silva, Francesca M. Lerner, Carl S. Wilkins, Stephen E. Valido, Daniel D. Klein, Celeste Y. Wu, Jake T. Neumann, David Della-Morte, Stephen H. Koslow, Alireza Minagar, Hung Wen Lin

Research output: Contribution to journal › Article › peer-review

Abstract

Sympathetic nervous system activity is increased after cardiopulmonary arrest, resulting in vasoconstrictor release from the perivascular sympathetic nerves of cerebral arteries. However, the pathophysiological function of the perivascular sympathetic nerves in the ischemic brain remains unclear. A rat model of global cerebral ischemia (asphyxial cardiac arrest, ACA) was used to investigate perivascular sympathetic nerves of cerebral arteries via bilateral decentralization (preganglionic lesion) of the superior cervical ganglion (SCG). Decentralization of the SCG 5 days before ACA alleviated hypoperfusion and afforded hippocampal neuroprotection and improved functional outcomes. These studies can provide further insights into the functional mechanism (s) of the sympathetic nervous system during ischemia. NEW & NOTEWORTHY Interruption of the perivascular sympathetic nerves can alleviate CA-induced hypoperfusion and neuronal cell death in the CA1 region of the hippocampus to enhance functional learning and memory.

Original language	English (US)
Pages (from-to)	H182-H188
Journal	American Journal of Physiology - Heart and Circulatory Physiology
Volume	312
Issue number	1
DOIs	https://doi.org/10.1152/ajpheart.00482.2016
State	Published - 2017
Externally published	Yes

Keywords

Behavior (rodent)
Brain ischemia
Cardiac arrest
Cerebral blood flow
Cerebral blood flow measurement
Cognitive impairment
Global ischemia
Neuroprotection
Pial vessels
Sympathetic nervous system
Two photon microscopy

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine
Physiology (medical)

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10.1152/ajpheart.00482.2016

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Lee, R. H., Couto e Silva, A., Lerner, F. M., Wilkins, C. S., Valido, S. E., Klein, D. D., Wu, C. Y., Neumann, J. T., Della-Morte, D., Koslow, S. H., Minagar, A., & Lin, H. W. (2017). Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia. American Journal of Physiology - Heart and Circulatory Physiology, 312(1), H182-H188. https://doi.org/10.1152/ajpheart.00482.2016

Lee, RH, Couto e Silva, A, Lerner, FM, Wilkins, CS, Valido, SE, Klein, DD, Wu, CY, Neumann, JT, Della-Morte, D, Koslow, SH, Minagar, A & Lin, HW 2017, 'Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia', American Journal of Physiology - Heart and Circulatory Physiology, vol. 312, no. 1, pp. H182-H188. https://doi.org/10.1152/ajpheart.00482.2016

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title = "Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia",

abstract = "Sympathetic nervous system activity is increased after cardiopulmonary arrest, resulting in vasoconstrictor release from the perivascular sympathetic nerves of cerebral arteries. However, the pathophysiological function of the perivascular sympathetic nerves in the ischemic brain remains unclear. A rat model of global cerebral ischemia (asphyxial cardiac arrest, ACA) was used to investigate perivascular sympathetic nerves of cerebral arteries via bilateral decentralization (preganglionic lesion) of the superior cervical ganglion (SCG). Decentralization of the SCG 5 days before ACA alleviated hypoperfusion and afforded hippocampal neuroprotection and improved functional outcomes. These studies can provide further insights into the functional mechanism (s) of the sympathetic nervous system during ischemia. NEW & NOTEWORTHY Interruption of the perivascular sympathetic nerves can alleviate CA-induced hypoperfusion and neuronal cell death in the CA1 region of the hippocampus to enhance functional learning and memory.",

keywords = "Behavior (rodent), Brain ischemia, Cardiac arrest, Cerebral blood flow, Cerebral blood flow measurement, Cognitive impairment, Global ischemia, Neuroprotection, Pial vessels, Sympathetic nervous system, Two photon microscopy",

author = "Lee, {Reggie H.} and {Couto e Silva}, Alexandre and Lerner, {Francesca M.} and Wilkins, {Carl S.} and Valido, {Stephen E.} and Klein, {Daniel D.} and Wu, {Celeste Y.} and Neumann, {Jake T.} and David Della-Morte and Koslow, {Stephen H.} and Alireza Minagar and Lin, {Hung Wen}",

note = "Funding Information: This work was supported by the American Heart Association Grants AHA-13SDG1395001413, Louisiana State University grant-in-aid research council, and Evelyn F. McKnight Brain Institute. Publisher Copyright: {\textcopyright} 2017 the American Physiological Society.",

year = "2017",

doi = "10.1152/ajpheart.00482.2016",

language = "English (US)",

volume = "312",

pages = "H182--H188",

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AU - Lee, Reggie H.

AU - Couto e Silva, Alexandre

AU - Lerner, Francesca M.

AU - Wilkins, Carl S.

AU - Valido, Stephen E.

AU - Klein, Daniel D.

AU - Wu, Celeste Y.

AU - Neumann, Jake T.

AU - Della-Morte, David

AU - Koslow, Stephen H.

AU - Minagar, Alireza

AU - Lin, Hung Wen

N1 - Funding Information: This work was supported by the American Heart Association Grants AHA-13SDG1395001413, Louisiana State University grant-in-aid research council, and Evelyn F. McKnight Brain Institute. Publisher Copyright: © 2017 the American Physiological Society.

PY - 2017

Y1 - 2017

N2 - Sympathetic nervous system activity is increased after cardiopulmonary arrest, resulting in vasoconstrictor release from the perivascular sympathetic nerves of cerebral arteries. However, the pathophysiological function of the perivascular sympathetic nerves in the ischemic brain remains unclear. A rat model of global cerebral ischemia (asphyxial cardiac arrest, ACA) was used to investigate perivascular sympathetic nerves of cerebral arteries via bilateral decentralization (preganglionic lesion) of the superior cervical ganglion (SCG). Decentralization of the SCG 5 days before ACA alleviated hypoperfusion and afforded hippocampal neuroprotection and improved functional outcomes. These studies can provide further insights into the functional mechanism (s) of the sympathetic nervous system during ischemia. NEW & NOTEWORTHY Interruption of the perivascular sympathetic nerves can alleviate CA-induced hypoperfusion and neuronal cell death in the CA1 region of the hippocampus to enhance functional learning and memory.

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Interruption of perivascular sympathetic nerves of cerebral arteries offers neuroprotection against ischemia

Abstract

Keywords

ASJC Scopus subject areas

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