Interrupting synoviolin play at the ER: A plausible action to elevate mitochondrial energetics and silence obesity

Meghan S. Soustek; Pere Puigserver

doi:10.15252/embj.201591240

Interrupting synoviolin play at the ER: A plausible action to elevate mitochondrial energetics and silence obesity

Meghan S. Soustek, Pere Puigserver

Research output: Contribution to journal › Article › peer-review

Abstract

Obesity is a global concern, which has been linked to increased risk for cardiovascular disease, type 2 diabetes, atherosclerosis, non-alcoholic fatty liver, and cancer. In this issue of The EMBO Journal, Fujita et al () describe the role of an endoplasmic reticulum (ER)-resident E3 ubiquitin ligase, synoviolin, and its ability to control body weight and energy expenditure by targeting PGC-1β, a transcriptional modulator of mitochondrial oxidative metabolism.

Original language	English (US)
Pages (from-to)	981-983
Number of pages	3
Journal	The EMBO journal
Volume	34
Issue number	8
DOIs	https://doi.org/10.15252/embj.201591240
State	Published - Apr 15 2015
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Neuroscience(all)

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Interrupting synoviolin play at the ER: A plausible action to elevate mitochondrial energetics and silence obesity

Abstract

ASJC Scopus subject areas

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