International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology

Jelena Rima Ghadri, Ilan Shor Wittstein, Abhiram Prasad, Scott Sharkey, Keigo Dote, Yoshihiro John Akashi, Victoria Lucia Cammann, Filippo Crea, Leonarda Galiuto, Walter Desmet, Tetsuro Yoshida, Roberto Manfredini, Ingo Eitel, Masami Kosuge, Holger M. Nef, Abhishek Deshmukh, Amir Lerman, Eduardo Bossone, Rodolfo Citro, Takashi UeyamaDomenico Corrado, Satoshi Kurisu, Frank Ruschitzka, David Winchester, Alexander R. Lyon, Elmir Omerovic, Jeroen J. Bax, Patrick Meimoun, Guiseppe Tarantini, Charanjit Rihal, Shams Y. Hassan, Federico Migliore, John D. Horowitz, Hiroaki Shimokawa, Thomas Felix Lüscher, Christian Templin

Research output: Contribution to journalArticlepeer-review

356 Scopus citations


Takotsubo syndrome (TTS) is a poorly recognized heart disease that was initially regarded as a benign condition. Recently, it has been shown that TTS may be associated with severe clinical complications including death and that its prevalence is probably underestimated. Since current guidelines on TTS are lacking, it appears timely and important to provide an expert consensus statement on TTS. The clinical expert consensus document part I summarizes the current state of knowledge on clinical presentation and characteristics of TTS and agrees on controversies surrounding TTS such as nomenclature, different TTS types, role of coronary artery disease, and etiology. This consensus also proposes new diagnostic criteria based on current knowledge to improve diagnostic accuracy.

Original languageEnglish (US)
Pages (from-to)2032-2046
Number of pages15
JournalEuropean heart journal
Issue number22
StatePublished - Jun 7 2018


  • Acute heart failure
  • Broken heart syndrome
  • Consensus statement
  • InterTAK Diagnostic Criteria
  • Takotsubo definition
  • Takotsubo syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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