International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

Sarah K. Wise; Cecelia Damask; Lauren T. Roland; Charles Ebert; Joshua M. Levy; Sandra Lin; Amber Luong; Kenneth Rodriguez; Ahmad R. Sedaghat; Elina Toskala; Jennifer Villwock; Baharudin Abdullah; Cezmi Akdis; Jeremiah A. Alt; Ignacio J. Ansotegui; Antoine Azar; Fuad Baroody; Michael S. Benninger; Jonathan Bernstein; Christopher Brook; Raewyn Campbell; Thomas Casale; Mohamad Chaaban; Fook Tim Chew; Jeffrey Chambliss; Antonella Cianferoni; Adnan Custovic; Elizabeth Mahoney Davis; John M. DelGaudio; Anne K. Ellis; Carrie Flanagan; Wytske J. Fokkens; Christine Franzese; Matthew Greenhawt; Amarbir Gill; Ashleigh Halderman; Jens M. Hohlfeld; Cristoforo Incorvaia; Stephanie A. Joe; Shyam Joshi; Merin Elizabeth Kuruvilla; Jean Kim; Adam M. Klein; Helene J. Krouse; Edward C. Kuan; David Lang; Desiree Larenas-Linnemann; Adrienne M. Laury; Matt Lechner; Stella E. Lee; Victoria S. Lee; Patricia Loftus; Sonya Marcus; Haidy Marzouk; Jose Mattos; Edward McCoul; Erik Melen; James W. Mims; Joaquim Mullol; Jayakar V. Nayak; John Oppenheimer; Richard R. Orlandi; Katie Phillips; Michael Platt; Murugappan Ramanathan; Mallory Raymond; Chae Seo Rhee; Sietze Reitsma; Matthew Ryan; Joaquin Sastre; Rodney J. Schlosser; Theodore A. Schuman; Marcus S. Shaker; Aziz Sheikh; Kristine A. Smith; Michael B. Soyka; Masayoshi Takashima; Monica Tang; Pongsakorn Tantilipikorn; Malcolm B. Taw; Jody Tversky; Matthew A. Tyler; Maria C. Veling; Dana Wallace; De Yun Wang; Andrew White; Luo Zhang; Omar G. Ahmed; Khashayar Arianpour; Emily Barrow; Carlo Cavaliere; Juan Carlos Ceballos Cantu; Mark B. Chaskes; Andy Jian Kai Chua; Srihari Daggumati; Luke Daines; Paul Daraei; Thomas Edwards; Deanna Gigliotti; Mitchell Gore; Khodayar Goshtasbi; Doo Hee Han; Lubnaa Hossenbaccus; Megan Jolicoeur; Dichapong Kanjanawasee; Suat Kilic; Sophia Linton; David Liu; Christoper Low; Chengetai Mahomva; Jordan A. Malenke; Amar Miglani; Peter Nagy; Jin A. Park; Marianella Paz-Lansberg; Paul Pfeffer; Marisa Ryan; Anirudh Saraswathula; Cameron Sheehan; Nadja Struss; Kevin Tie; Sina Torabi; Esmond F. Tsai; Nathalia Velasquez; Jackson Vuncannon; Duncan Watley; Xinni Xu

doi:10.1002/alr.23090

International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

Sarah K. Wise, Cecelia Damask, Lauren T. Roland, Charles Ebert, Joshua M. Levy, Sandra Lin, Amber Luong, Kenneth Rodriguez, Ahmad R. Sedaghat, Elina Toskala, Jennifer Villwock, Baharudin Abdullah, Cezmi Akdis, Jeremiah A. Alt, Ignacio J. Ansotegui, Antoine Azar, Fuad Baroody, Michael S. Benninger, Jonathan Bernstein, Christopher BrookRaewyn Campbell, Thomas Casale, Mohamad Chaaban, Fook Tim Chew, Jeffrey Chambliss, Antonella Cianferoni, Adnan Custovic, Elizabeth Mahoney Davis, John M. DelGaudio, Anne K. Ellis, Carrie Flanagan, Wytske J. Fokkens, Christine Franzese, Matthew Greenhawt, Amarbir Gill, Ashleigh Halderman, Jens M. Hohlfeld, Cristoforo Incorvaia, Stephanie A. Joe, Shyam Joshi, Merin Elizabeth Kuruvilla, Jean Kim, Adam M. Klein, Helene J. Krouse, Edward C. Kuan, David Lang, Desiree Larenas-Linnemann, Adrienne M. Laury, Matt Lechner, Stella E. Lee, Victoria S. Lee, Patricia Loftus, Sonya Marcus, Haidy Marzouk, Jose Mattos, Edward McCoul, Erik Melen, James W. Mims, Joaquim Mullol, Jayakar V. Nayak, John Oppenheimer, Richard R. Orlandi, Katie Phillips, Michael Platt, Murugappan Ramanathan, Mallory Raymond, Chae Seo Rhee, Sietze Reitsma, Matthew Ryan, Joaquin Sastre, Rodney J. Schlosser, Theodore A. Schuman, Marcus S. Shaker, Aziz Sheikh, Kristine A. Smith, Michael B. Soyka, Masayoshi Takashima, Monica Tang, Pongsakorn Tantilipikorn, Malcolm B. Taw, Jody Tversky, Matthew A. Tyler, Maria C. Veling, Dana Wallace, De Yun Wang, Andrew White, Luo Zhang, Omar G. Ahmed, Khashayar Arianpour, Emily Barrow, Carlo Cavaliere, Juan Carlos Ceballos Cantu, Mark B. Chaskes, Andy Jian Kai Chua, Srihari Daggumati, Luke Daines, Paul Daraei, Thomas Edwards, Deanna Gigliotti, Mitchell Gore, Khodayar Goshtasbi, Doo Hee Han, Lubnaa Hossenbaccus, Megan Jolicoeur, Dichapong Kanjanawasee, Suat Kilic, Sophia Linton, David Liu, Christoper Low, Chengetai Mahomva, Jordan A. Malenke, Amar Miglani, Peter Nagy, Jin A. Park, Marianella Paz-Lansberg, Paul Pfeffer, Marisa Ryan, Anirudh Saraswathula, Cameron Sheehan, Nadja Struss, Kevin Tie, Sina Torabi, Esmond F. Tsai, Nathalia Velasquez, Jackson Vuncannon, Duncan Watley, Xinni Xu

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Background: In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence-based findings and recommendation from the full document. Methods: ICAR-Allergic Rhinitis 2023 employed established evidence-based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus was performed for each topic. The final document was then collated and includes the results of this work. Results: ICAR-Allergic Rhinitis 2023 includes 10 major content areas and 144 individual topics related to AR. For a substantial proportion of topics included, an aggregate grade of evidence is presented, which is determined by collating the levels of evidence for each available study identified in the literature. For topics in which a diagnostic or therapeutic intervention is considered, a recommendation summary is presented, which considers the aggregate grade of evidence, benefit, harm, and cost. Conclusion: The ICAR-Allergic Rhinitis 2023 update provides a comprehensive evaluation of AR and the currently available evidence. It is this evidence that contributes to our current knowledge base and recommendations for patient evaluation and treatment.

Original language	English (US)
Pages (from-to)	293-859
Number of pages	567
Journal	International Forum of Allergy and Rhinology
Volume	13
Issue number	4
DOIs	https://doi.org/10.1002/alr.23090
State	Published - Apr 2023

Keywords

IgE
allergen extract
allergen immunotherapy
allergic rhinitis
allergy
antihistamine
asthma
atopic dermatitis
avoidance
biologic
cockroach
conjunctivitis
consensus
corticosteroid
cough
cromolyn
decongestant
environment
eosinophilic esophagitis
epicutaneous
epidemiology
evidence-based medicine
food allergy
house dust mite
immunoglobulin E
immunotherapy
inhalant allergy
leukotriene
microbiome
occupational rhinitis
omalizumab
pediatric
perennial
pet dander
pollen
probiotic
rhinitis
rhinosinusitis
saline
seasonal
sensitization
sinusitis
socioeconomic
specific IgE
subcutaneous immunotherapy
sublingual immunotherapy
systematic review
total IgE
transcutaneous immunotherapy
validated survey

ASJC Scopus subject areas

Immunology and Allergy
Otorhinolaryngology

Access to Document

10.1002/alr.23090

Cite this

Wise, S. K., Damask, C., Roland, L. T., Ebert, C., Levy, J. M., Lin, S., Luong, A., Rodriguez, K., Sedaghat, A. R., Toskala, E., Villwock, J., Abdullah, B., Akdis, C., Alt, J. A., Ansotegui, I. J., Azar, A., Baroody, F., Benninger, M. S., Bernstein, J., ... Xu, X. (2023). International consensus statement on allergy and rhinology: Allergic rhinitis – 2023. International Forum of Allergy and Rhinology, 13(4), 293-859. https://doi.org/10.1002/alr.23090

Wise, SK, Damask, C, Roland, LT, Ebert, C, Levy, JM, Lin, S, Luong, A, Rodriguez, K, Sedaghat, AR, Toskala, E, Villwock, J, Abdullah, B, Akdis, C, Alt, JA, Ansotegui, IJ, Azar, A, Baroody, F, Benninger, MS, Bernstein, J, Brook, C, Campbell, R, Casale, T, Chaaban, M, Chew, FT, Chambliss, J, Cianferoni, A, Custovic, A, Davis, EM, DelGaudio, JM, Ellis, AK, Flanagan, C, Fokkens, WJ, Franzese, C, Greenhawt, M, Gill, A, Halderman, A, Hohlfeld, JM, Incorvaia, C, Joe, SA, Joshi, S, Kuruvilla, ME, Kim, J, Klein, AM, Krouse, HJ, Kuan, EC, Lang, D, Larenas-Linnemann, D, Laury, AM, Lechner, M, Lee, SE, Lee, VS, Loftus, P, Marcus, S, Marzouk, H, Mattos, J, McCoul, E, Melen, E, Mims, JW, Mullol, J, Nayak, JV, Oppenheimer, J, Orlandi, RR, Phillips, K, Platt, M, Ramanathan, M, Raymond, M, Rhee, CS, Reitsma, S, Ryan, M, Sastre, J, Schlosser, RJ, Schuman, TA, Shaker, MS, Sheikh, A, Smith, KA, Soyka, MB, Takashima, M, Tang, M, Tantilipikorn, P, Taw, MB, Tversky, J, Tyler, MA, Veling, MC, Wallace, D, Wang, DY, White, A, Zhang, L, Ahmed, OG, Arianpour, K, Barrow, E, Cavaliere, C, Cantu, JCC, Chaskes, MB, Chua, AJK, Daggumati, S, Daines, L, Daraei, P, Edwards, T, Gigliotti, D, Gore, M, Goshtasbi, K, Han, DH, Hossenbaccus, L, Jolicoeur, M, Kanjanawasee, D, Kilic, S, Linton, S, Liu, D, Low, C, Mahomva, C, Malenke, JA, Miglani, A, Nagy, P, Park, JA, Paz-Lansberg, M, Pfeffer, P, Ryan, M, Saraswathula, A, Sheehan, C, Struss, N, Tie, K, Torabi, S, Tsai, EF, Velasquez, N, Vuncannon, J, Watley, D & Xu, X 2023, 'International consensus statement on allergy and rhinology: Allergic rhinitis – 2023', International Forum of Allergy and Rhinology, vol. 13, no. 4, pp. 293-859. https://doi.org/10.1002/alr.23090

@article{f5068a790492479fa7403853b810feec,

title = "International consensus statement on allergy and rhinology: Allergic rhinitis – 2023",

abstract = "Background: In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence-based findings and recommendation from the full document. Methods: ICAR-Allergic Rhinitis 2023 employed established evidence-based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus was performed for each topic. The final document was then collated and includes the results of this work. Results: ICAR-Allergic Rhinitis 2023 includes 10 major content areas and 144 individual topics related to AR. For a substantial proportion of topics included, an aggregate grade of evidence is presented, which is determined by collating the levels of evidence for each available study identified in the literature. For topics in which a diagnostic or therapeutic intervention is considered, a recommendation summary is presented, which considers the aggregate grade of evidence, benefit, harm, and cost. Conclusion: The ICAR-Allergic Rhinitis 2023 update provides a comprehensive evaluation of AR and the currently available evidence. It is this evidence that contributes to our current knowledge base and recommendations for patient evaluation and treatment.",

keywords = "IgE, allergen extract, allergen immunotherapy, allergic rhinitis, allergy, antihistamine, asthma, atopic dermatitis, avoidance, biologic, cockroach, conjunctivitis, consensus, corticosteroid, cough, cromolyn, decongestant, environment, eosinophilic esophagitis, epicutaneous, epidemiology, evidence-based medicine, food allergy, house dust mite, immunoglobulin E, immunotherapy, inhalant allergy, leukotriene, microbiome, occupational rhinitis, omalizumab, pediatric, perennial, pet dander, pollen, probiotic, rhinitis, rhinosinusitis, saline, seasonal, sensitization, sinusitis, socioeconomic, specific IgE, subcutaneous immunotherapy, sublingual immunotherapy, systematic review, total IgE, transcutaneous immunotherapy, validated survey",

author = "Wise, {Sarah K.} and Cecelia Damask and Roland, {Lauren T.} and Charles Ebert and Levy, {Joshua M.} and Sandra Lin and Amber Luong and Kenneth Rodriguez and Sedaghat, {Ahmad R.} and Elina Toskala and Jennifer Villwock and Baharudin Abdullah and Cezmi Akdis and Alt, {Jeremiah A.} and Ansotegui, {Ignacio J.} and Antoine Azar and Fuad Baroody and Benninger, {Michael S.} and Jonathan Bernstein and Christopher Brook and Raewyn Campbell and Thomas Casale and Mohamad Chaaban and Chew, {Fook Tim} and Jeffrey Chambliss and Antonella Cianferoni and Adnan Custovic and Davis, {Elizabeth Mahoney} and DelGaudio, {John M.} and Ellis, {Anne K.} and Carrie Flanagan and Fokkens, {Wytske J.} and Christine Franzese and Matthew Greenhawt and Amarbir Gill and Ashleigh Halderman and Hohlfeld, {Jens M.} and Cristoforo Incorvaia and Joe, {Stephanie A.} and Shyam Joshi and Kuruvilla, {Merin Elizabeth} and Jean Kim and Klein, {Adam M.} and Krouse, {Helene J.} and Kuan, {Edward C.} and David Lang and Desiree Larenas-Linnemann and Laury, {Adrienne M.} and Matt Lechner and Lee, {Stella E.} and Lee, {Victoria S.} and Patricia Loftus and Sonya Marcus and Haidy Marzouk and Jose Mattos and Edward McCoul and Erik Melen and Mims, {James W.} and Joaquim Mullol and Nayak, {Jayakar V.} and John Oppenheimer and Orlandi, {Richard R.} and Katie Phillips and Michael Platt and Murugappan Ramanathan and Mallory Raymond and Rhee, {Chae Seo} and Sietze Reitsma and Matthew Ryan and Joaquin Sastre and Schlosser, {Rodney J.} and Schuman, {Theodore A.} and Shaker, {Marcus S.} and Aziz Sheikh and Smith, {Kristine A.} and Soyka, {Michael B.} and Masayoshi Takashima and Monica Tang and Pongsakorn Tantilipikorn and Taw, {Malcolm B.} and Jody Tversky and Tyler, {Matthew A.} and Veling, {Maria C.} and Dana Wallace and Wang, {De Yun} and Andrew White and Luo Zhang and Ahmed, {Omar G.} and Khashayar Arianpour and Emily Barrow and Carlo Cavaliere and Cantu, {Juan Carlos Ceballos} and Chaskes, {Mark B.} and Chua, {Andy Jian Kai} and Srihari Daggumati and Luke Daines and Paul Daraei and Thomas Edwards and Deanna Gigliotti and Mitchell Gore and Khodayar Goshtasbi and Han, {Doo Hee} and Lubnaa Hossenbaccus and Megan Jolicoeur and Dichapong Kanjanawasee and Suat Kilic and Sophia Linton and David Liu and Christoper Low and Chengetai Mahomva and Malenke, {Jordan A.} and Amar Miglani and Peter Nagy and Park, {Jin A.} and Marianella Paz-Lansberg and Paul Pfeffer and Marisa Ryan and Anirudh Saraswathula and Cameron Sheehan and Nadja Struss and Kevin Tie and Sina Torabi and Tsai, {Esmond F.} and Nathalia Velasquez and Jackson Vuncannon and Duncan Watley and Xinni Xu",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. International Forum of Allergy & Rhinology published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.",

year = "2023",

month = apr,

doi = "10.1002/alr.23090",

language = "English (US)",

volume = "13",

pages = "293--859",

journal = "International Forum of Allergy and Rhinology",

issn = "2042-6976",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - International consensus statement on allergy and rhinology

T2 - Allergic rhinitis – 2023

AU - Wise, Sarah K.

AU - Damask, Cecelia

AU - Roland, Lauren T.

AU - Ebert, Charles

AU - Levy, Joshua M.

AU - Lin, Sandra

AU - Luong, Amber

AU - Rodriguez, Kenneth

AU - Sedaghat, Ahmad R.

AU - Toskala, Elina

AU - Villwock, Jennifer

AU - Abdullah, Baharudin

AU - Akdis, Cezmi

AU - Alt, Jeremiah A.

AU - Ansotegui, Ignacio J.

AU - Azar, Antoine

AU - Baroody, Fuad

AU - Benninger, Michael S.

AU - Bernstein, Jonathan

AU - Brook, Christopher

AU - Campbell, Raewyn

AU - Casale, Thomas

AU - Chaaban, Mohamad

AU - Chew, Fook Tim

AU - Chambliss, Jeffrey

AU - Cianferoni, Antonella

AU - Custovic, Adnan

AU - Davis, Elizabeth Mahoney

AU - DelGaudio, John M.

AU - Ellis, Anne K.

AU - Flanagan, Carrie

AU - Fokkens, Wytske J.

AU - Franzese, Christine

AU - Greenhawt, Matthew

AU - Gill, Amarbir

AU - Halderman, Ashleigh

AU - Hohlfeld, Jens M.

AU - Incorvaia, Cristoforo

AU - Joe, Stephanie A.

AU - Joshi, Shyam

AU - Kuruvilla, Merin Elizabeth

AU - Kim, Jean

AU - Klein, Adam M.

AU - Krouse, Helene J.

AU - Kuan, Edward C.

AU - Lang, David

AU - Larenas-Linnemann, Desiree

AU - Laury, Adrienne M.

AU - Lechner, Matt

AU - Lee, Stella E.

AU - Lee, Victoria S.

AU - Loftus, Patricia

AU - Marcus, Sonya

AU - Marzouk, Haidy

AU - Mattos, Jose

AU - McCoul, Edward

AU - Melen, Erik

AU - Mims, James W.

AU - Mullol, Joaquim

AU - Nayak, Jayakar V.

AU - Oppenheimer, John

AU - Orlandi, Richard R.

AU - Phillips, Katie

AU - Platt, Michael

AU - Ramanathan, Murugappan

AU - Raymond, Mallory

AU - Rhee, Chae Seo

AU - Reitsma, Sietze

AU - Ryan, Matthew

AU - Sastre, Joaquin

AU - Schlosser, Rodney J.

AU - Schuman, Theodore A.

AU - Shaker, Marcus S.

AU - Sheikh, Aziz

AU - Smith, Kristine A.

AU - Soyka, Michael B.

AU - Takashima, Masayoshi

AU - Tang, Monica

AU - Tantilipikorn, Pongsakorn

AU - Taw, Malcolm B.

AU - Tversky, Jody

AU - Tyler, Matthew A.

AU - Veling, Maria C.

AU - Wallace, Dana

AU - Wang, De Yun

AU - White, Andrew

AU - Zhang, Luo

AU - Ahmed, Omar G.

AU - Arianpour, Khashayar

AU - Barrow, Emily

AU - Cavaliere, Carlo

AU - Cantu, Juan Carlos Ceballos

AU - Chaskes, Mark B.

AU - Chua, Andy Jian Kai

AU - Daggumati, Srihari

AU - Daines, Luke

AU - Daraei, Paul

AU - Edwards, Thomas

AU - Gigliotti, Deanna

AU - Gore, Mitchell

AU - Goshtasbi, Khodayar

AU - Han, Doo Hee

AU - Hossenbaccus, Lubnaa

AU - Jolicoeur, Megan

AU - Kanjanawasee, Dichapong

AU - Kilic, Suat

AU - Linton, Sophia

AU - Liu, David

AU - Low, Christoper

AU - Mahomva, Chengetai

AU - Malenke, Jordan A.

AU - Miglani, Amar

AU - Nagy, Peter

AU - Park, Jin A.

AU - Paz-Lansberg, Marianella

AU - Pfeffer, Paul

AU - Ryan, Marisa

AU - Saraswathula, Anirudh

AU - Sheehan, Cameron

AU - Struss, Nadja

AU - Tie, Kevin

AU - Torabi, Sina

AU - Tsai, Esmond F.

AU - Velasquez, Nathalia

AU - Vuncannon, Jackson

AU - Watley, Duncan

AU - Xu, Xinni

N1 - Publisher Copyright: © 2023 The Authors. International Forum of Allergy & Rhinology published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society.

PY - 2023/4

Y1 - 2023/4

N2 - Background: In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence-based findings and recommendation from the full document. Methods: ICAR-Allergic Rhinitis 2023 employed established evidence-based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus was performed for each topic. The final document was then collated and includes the results of this work. Results: ICAR-Allergic Rhinitis 2023 includes 10 major content areas and 144 individual topics related to AR. For a substantial proportion of topics included, an aggregate grade of evidence is presented, which is determined by collating the levels of evidence for each available study identified in the literature. For topics in which a diagnostic or therapeutic intervention is considered, a recommendation summary is presented, which considers the aggregate grade of evidence, benefit, harm, and cost. Conclusion: The ICAR-Allergic Rhinitis 2023 update provides a comprehensive evaluation of AR and the currently available evidence. It is this evidence that contributes to our current knowledge base and recommendations for patient evaluation and treatment.

AB - Background: In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rhinitis 2023 update presents 144 individual topics on allergic rhinitis (AR), expanded by over 40 topics from the 2018 document. Originally presented topics from 2018 have also been reviewed and updated. The executive summary highlights key evidence-based findings and recommendation from the full document. Methods: ICAR-Allergic Rhinitis 2023 employed established evidence-based review with recommendation (EBRR) methodology to individually evaluate each topic. Stepwise iterative peer review and consensus was performed for each topic. The final document was then collated and includes the results of this work. Results: ICAR-Allergic Rhinitis 2023 includes 10 major content areas and 144 individual topics related to AR. For a substantial proportion of topics included, an aggregate grade of evidence is presented, which is determined by collating the levels of evidence for each available study identified in the literature. For topics in which a diagnostic or therapeutic intervention is considered, a recommendation summary is presented, which considers the aggregate grade of evidence, benefit, harm, and cost. Conclusion: The ICAR-Allergic Rhinitis 2023 update provides a comprehensive evaluation of AR and the currently available evidence. It is this evidence that contributes to our current knowledge base and recommendations for patient evaluation and treatment.

KW - IgE

KW - allergen extract

KW - allergen immunotherapy

KW - allergic rhinitis

KW - allergy

KW - antihistamine

KW - asthma

KW - atopic dermatitis

KW - avoidance

KW - biologic

KW - cockroach

KW - conjunctivitis

KW - consensus

KW - corticosteroid

KW - cough

KW - cromolyn

KW - decongestant

KW - environment

KW - eosinophilic esophagitis

KW - epicutaneous

KW - epidemiology

KW - evidence-based medicine

KW - food allergy

KW - house dust mite

KW - immunoglobulin E

KW - immunotherapy

KW - inhalant allergy

KW - leukotriene

KW - microbiome

KW - occupational rhinitis

KW - omalizumab

KW - pediatric

KW - perennial

KW - pet dander

KW - pollen

KW - probiotic

KW - rhinitis

KW - rhinosinusitis

KW - saline

KW - seasonal

KW - sensitization

KW - sinusitis

KW - socioeconomic

KW - specific IgE

KW - subcutaneous immunotherapy

KW - sublingual immunotherapy

KW - systematic review

KW - total IgE

KW - transcutaneous immunotherapy

KW - validated survey

UR - http://www.scopus.com/inward/record.url?scp=85149200988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85149200988&partnerID=8YFLogxK

U2 - 10.1002/alr.23090

DO - 10.1002/alr.23090

M3 - Review article

C2 - 36878860

AN - SCOPUS:85149200988

SN - 2042-6976

VL - 13

SP - 293

EP - 859

JO - International Forum of Allergy and Rhinology

JF - International Forum of Allergy and Rhinology

IS - 4

ER -

International consensus statement on allergy and rhinology: Allergic rhinitis – 2023

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