International Consensus Classification of acute lymphoblastic leukemia/lymphoma

Amy S Duffield, Charles G. Mullighan, Michael J. Borowitz

Research output: Contribution to journalReview articlepeer-review

Abstract

The updated International Consensus Classification (ICC) of B-acute lymphoblastic leukemia (B-ALL) and T-acute lymphoblastic leukemia (T-ALL) includes both revisions to subtypes previously outlined in the 2016 WHO classification and several newly described entities. The ICC classification incorporates recent clinical, cytogenetic, and molecular data, with a particular emphasis on whole transcriptome analysis and gene expression (GEX) clustering studies. B-ALL classification is modified to further subclassify BCR::ABL1-positive B-ALL and hypodiploid B-ALL. Additionally, nine new categories of B-ALL are defined, including seven that contain distinguishing gene rearrangements, as well as two new categories that are characterized by a specific single gene mutation. Four provisional entities are also included in the updated B-ALL classification, although definitive identification of these subtypes requires GEX studies. T-ALL classification is also updated to incorporate BCL11B-activating rearrangements into early T-precursor (ETP) ALL taxonomy. Additionally, eight new provisional entities are added to the T-ALL subclassification. The clinical implications of the new entities are discussed, as are practical approaches to the use of different technologies in diagnosis. The enhanced specificity of the new classification will allow for improved risk stratification and optimized treatment plans for patients with ALL.

Original languageEnglish (US)
Pages (from-to)11-26
Number of pages16
JournalVirchows Archiv
Volume482
Issue number1
DOIs
StatePublished - Jan 2023

Keywords

  • B-lymphoblastic leukemia
  • B-lymphoblastic lymphoma
  • Gene expression clustering
  • T-lymphoblastic leukemia
  • T-lymphoblastic lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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