Intermittent fasting: A "new" historical strategy for controlling seizures?

Adam L. Hartman, James E. Rubenstein, Eric H. Kossoff

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


In antiquity, fasting was a treatment for epilepsy and a rationale for the ketogenic diet (KD). Preclinical data indicate the KD and intermittent fasting do not share identical anticonvulsant mechanisms. We implemented an intermittent fasting regimen in six children with an incomplete response to a KD. Three patients adhered to the combined intermittent fasting/KD regimen for 2 months and four had transient improvement in seizure control, albeit with some hunger-related adverse reactions.

Original languageEnglish (US)
Pages (from-to)275-279
Number of pages5
JournalEpilepsy Research
Issue number3
StatePublished - May 2013


  • Children
  • Intermittent fasting
  • Ketogenic diet
  • Medically intractable epilepsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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