Intermittent fasting: A "new" historical strategy for controlling seizures?

Adam L. Hartman; James E. Rubenstein; Eric H. Kossoff

doi:10.1016/j.eplepsyres.2012.10.011

Intermittent fasting: A "new" historical strategy for controlling seizures?

Adam L. Hartman, James E. Rubenstein, Eric H. Kossoff

School of Medicine

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

In antiquity, fasting was a treatment for epilepsy and a rationale for the ketogenic diet (KD). Preclinical data indicate the KD and intermittent fasting do not share identical anticonvulsant mechanisms. We implemented an intermittent fasting regimen in six children with an incomplete response to a KD. Three patients adhered to the combined intermittent fasting/KD regimen for 2 months and four had transient improvement in seizure control, albeit with some hunger-related adverse reactions.

Original language	English (US)
Pages (from-to)	275-279
Number of pages	5
Journal	Epilepsy Research
Volume	104
Issue number	3
DOIs	https://doi.org/10.1016/j.eplepsyres.2012.10.011
State	Published - May 2013

Keywords

Children
Intermittent fasting
Ketogenic diet
Medically intractable epilepsy

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/j.eplepsyres.2012.10.011

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abstract = "In antiquity, fasting was a treatment for epilepsy and a rationale for the ketogenic diet (KD). Preclinical data indicate the KD and intermittent fasting do not share identical anticonvulsant mechanisms. We implemented an intermittent fasting regimen in six children with an incomplete response to a KD. Three patients adhered to the combined intermittent fasting/KD regimen for 2 months and four had transient improvement in seizure control, albeit with some hunger-related adverse reactions.",

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AB - In antiquity, fasting was a treatment for epilepsy and a rationale for the ketogenic diet (KD). Preclinical data indicate the KD and intermittent fasting do not share identical anticonvulsant mechanisms. We implemented an intermittent fasting regimen in six children with an incomplete response to a KD. Three patients adhered to the combined intermittent fasting/KD regimen for 2 months and four had transient improvement in seizure control, albeit with some hunger-related adverse reactions.

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Intermittent fasting: A "new" historical strategy for controlling seizures?

Abstract

Keywords

ASJC Scopus subject areas

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