Abstract
To determine the anti-ischemic mechanism of intermittent occlusion of the coronary sinus (ICSO), the authors measured coronary arterial and sinus pressure and coronary arterial oxygen saturation before and after coronary artery litigation, with and without ICSO. In dogs, ICSO produced a systolic pressure gradient between the coronary artery and coronary sinus of -20 ± 9 mm Hg (higher venous pressure, p <0.001) and a reduction in the oxygen of 20 ± 13% (p <0.005). In parallel studies the authors constructed a mathematical model of known physiology to test the possibility of venoarterial flow. Predicted and experimental data were similar, indicating a reversal of flow at the microcirculatory level of ischemic regions during ISCO. These data indicate that alternating arteriovenous and venoarterial flow over the ischemic territory is the anti-ischemic mechanism of ICSO.
| Original language | English (US) |
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| Title of host publication | IEEE/Engineering in Medicine and Biology Society Annual Conference |
| Publisher | Publ by IEEE |
| Pages | 52 |
| Number of pages | 1 |
| Volume | 10 |
| Edition | pt 1 |
| State | Published - Nov 1988 |
| Event | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society - New Orleans, LA, USA Duration: Nov 4 1988 → Nov 7 1988 |
Other
| Other | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
|---|---|
| City | New Orleans, LA, USA |
| Period | 11/4/88 → 11/7/88 |
ASJC Scopus subject areas
- Engineering(all)