Intermittent chemoprophylaxis for Pneumocystis carinii pneumonia

W. T. Hughes, B. L. Smith

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


An intermittent regimen of trimethoprim-sulfamethoxazole was tested in the corticosteroid-treated rat model to learn whether or not administration for 3 consecutive days a week would provide prophylaxis equal to continuous daily doses. Although all of the untreated control animals acquired Pneumocystis carinii pneumonia, none of the animals given either continuous or intermittent trimethoprim-sulfanethoxazole became infected.

Original languageEnglish (US)
Pages (from-to)300-301
Number of pages2
JournalAntimicrobial agents and chemotherapy
Issue number2
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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