Interleukin (IL)-12 and IL-23 are key cytokines for immunity against salmonella in humans

Calman MacLennan; Claire Fieschi; David A. Lammas; Capucine Picard; Susan E. Dorman; Dzden Sanal; Jenny M. MacLennan; Steven M. Holland; Tom H.M. Dttenhoff; Jean Laurent Casanova; Dinakantha S. Kumararatne

doi:10.1086/425021

Interleukin (IL)-12 and IL-23 are key cytokines for immunity against salmonella in humans

Calman MacLennan, Claire Fieschi, David A. Lammas, Capucine Picard, Susan E. Dorman, Dzden Sanal, Jenny M. MacLennan, Steven M. Holland, Tom H.M. Dttenhoff, Jean Laurent Casanova, Dinakantha S. Kumararatne

Research output: Contribution to journal › Article › peer-review

143 Scopus citations

Abstract

Patients with inherited deficiency of the interleukin (IL)-12/ IL-23-interferon (IFN)-γ axis show increased susceptibility to invasive disease caused by the intramacrophage pathogens salmonellae and mycobacteria. We analyzed data on 154 patients with such deficiency. Significantly more patients with IL-12/ IL-23-component deficiency had a history of salmonella disease than did those with IFN-γ-component deficiency. Salmonella disease was typically severe, extraintestinal, and caused by nontyphoidal serovars. These findings strongly suggest that IL-12/IL-23 is a key cytokine for immunity against salmonella in humans and that IL-12/IL-23 mediates this protective effect partly through IFN-γ-independent pathways. Investigation of the IL-12/IL-23-IFN-γ axis should be considered in patients with invasive salmonella disease.

Original language	English (US)
Pages (from-to)	1755-1757
Number of pages	3
Journal	Journal of Infectious Diseases
Volume	190
Issue number	10
DOIs	https://doi.org/10.1086/425021
State	Published - Nov 15 2004
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1086/425021

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@article{892239a6e28449f3a9616cb73f4b48c9,

title = "Interleukin (IL)-12 and IL-23 are key cytokines for immunity against salmonella in humans",

abstract = "Patients with inherited deficiency of the interleukin (IL)-12/ IL-23-interferon (IFN)-γ axis show increased susceptibility to invasive disease caused by the intramacrophage pathogens salmonellae and mycobacteria. We analyzed data on 154 patients with such deficiency. Significantly more patients with IL-12/ IL-23-component deficiency had a history of salmonella disease than did those with IFN-γ-component deficiency. Salmonella disease was typically severe, extraintestinal, and caused by nontyphoidal serovars. These findings strongly suggest that IL-12/IL-23 is a key cytokine for immunity against salmonella in humans and that IL-12/IL-23 mediates this protective effect partly through IFN-γ-independent pathways. Investigation of the IL-12/IL-23-IFN-γ axis should be considered in patients with invasive salmonella disease.",

author = "Calman MacLennan and Claire Fieschi and Lammas, {David A.} and Capucine Picard and Dorman, {Susan E.} and Dzden Sanal and MacLennan, {Jenny M.} and Holland, {Steven M.} and Dttenhoff, {Tom H.M.} and Casanova, {Jean Laurent} and Kumararatne, {Dinakantha S.}",

note = "Funding Information: Financial support: Endowment Research Fund of the United Hospital of Birmingham (grant 12.3.557 to C.M.); Research Training Fellowship in Clinical Tropical Medicine from the Wellcome Trust (GR067902MF to C.M.); Medical Research Council Cooperative Group (grant G9901077 to D.A.L.).",

year = "2004",

month = nov,

day = "15",

doi = "10.1086/425021",

language = "English (US)",

volume = "190",

pages = "1755--1757",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Interleukin (IL)-12 and IL-23 are key cytokines for immunity against salmonella in humans

AU - MacLennan, Calman

AU - Fieschi, Claire

AU - Lammas, David A.

AU - Picard, Capucine

AU - Dorman, Susan E.

AU - Sanal, Dzden

AU - MacLennan, Jenny M.

AU - Holland, Steven M.

AU - Dttenhoff, Tom H.M.

AU - Casanova, Jean Laurent

AU - Kumararatne, Dinakantha S.

N1 - Funding Information: Financial support: Endowment Research Fund of the United Hospital of Birmingham (grant 12.3.557 to C.M.); Research Training Fellowship in Clinical Tropical Medicine from the Wellcome Trust (GR067902MF to C.M.); Medical Research Council Cooperative Group (grant G9901077 to D.A.L.).

PY - 2004/11/15

Y1 - 2004/11/15

N2 - Patients with inherited deficiency of the interleukin (IL)-12/ IL-23-interferon (IFN)-γ axis show increased susceptibility to invasive disease caused by the intramacrophage pathogens salmonellae and mycobacteria. We analyzed data on 154 patients with such deficiency. Significantly more patients with IL-12/ IL-23-component deficiency had a history of salmonella disease than did those with IFN-γ-component deficiency. Salmonella disease was typically severe, extraintestinal, and caused by nontyphoidal serovars. These findings strongly suggest that IL-12/IL-23 is a key cytokine for immunity against salmonella in humans and that IL-12/IL-23 mediates this protective effect partly through IFN-γ-independent pathways. Investigation of the IL-12/IL-23-IFN-γ axis should be considered in patients with invasive salmonella disease.

AB - Patients with inherited deficiency of the interleukin (IL)-12/ IL-23-interferon (IFN)-γ axis show increased susceptibility to invasive disease caused by the intramacrophage pathogens salmonellae and mycobacteria. We analyzed data on 154 patients with such deficiency. Significantly more patients with IL-12/ IL-23-component deficiency had a history of salmonella disease than did those with IFN-γ-component deficiency. Salmonella disease was typically severe, extraintestinal, and caused by nontyphoidal serovars. These findings strongly suggest that IL-12/IL-23 is a key cytokine for immunity against salmonella in humans and that IL-12/IL-23 mediates this protective effect partly through IFN-γ-independent pathways. Investigation of the IL-12/IL-23-IFN-γ axis should be considered in patients with invasive salmonella disease.

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Interleukin (IL)-12 and IL-23 are key cytokines for immunity against salmonella in humans

Abstract

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