Abstract
Behçet's disease (BD) is an autoimmune disease of unknown etiology. Interleukin-28A (IL-28A) promotes immune responses and may participate in the pathogenesis of autoimmune diseases. To examine the role of IL-28A in the pathogenesis of BD, we measured the expression of IFN-γ and IL-17 by IL-28A-stimulated peripheral blood mononuclear cells (PBMCs) from 19 patients with BD and 16 healthy individuals. We found that IFN-γ and IL-17 were undetectable in the sera from BD patients and control subjects. The mRNA expression and protein production of IFN-γ by IL-28A-stimulated PBMCs from BD patients were significantly increased compared to healthy individuals. No significant difference was observed in the mRNA expression and protein production of IL-17 by IL-28A-stimulated PBMCs between BD patients and normal individuals.
Original language | English (US) |
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Pages (from-to) | 116-119 |
Number of pages | 4 |
Journal | Cellular Immunology |
Volume | 290 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2014 |
Externally published | Yes |
Keywords
- Behçet's disease
- Cytokine
- IL-28A
- PBMCs
ASJC Scopus subject areas
- Immunology