@article{24ed68d760b5415390e1cf28e9651e4b,
title = "Interferon lambda 3 genotype predicts hepatitis C virus RNA levels in early acute infection among people who inject drugs: The InC3 Study",
abstract = "Background and objectives: Hepatitis C virus (HCV) RNA level in acute HCV infection is predictive of spontaneous clearance. This study assessed factors associated with HCV RNA levels during early acute infection among people who inject drugs with well-defined acute HCV infection. Study design: Data were from International Collaboration of Incident HIV and Hepatitis C in Injecting Cohorts (InC3) Study, an international collaboration of nine prospective cohorts studying acute HCV infection. Individuals with available HCV RNA levels during early acute infection (first two months following infection) were included. The distribution of HCV RNA levels during early acute infection were compared by selected host and virological factors. Results: A total of 195 individuals were included. Median HCV RNA levels were significantly higher among individuals with interferon lambda 3 (IFNL3, formerly called IL28B) CC genotype compared to those with TT/CT genotype (6.28 vs. 5.39. log. IU/mL, respectively; P= 0.01). IFNL3 CC genotype was also associated with top tertile HCV RNA levels (≥6.3. logIU/mL; vs. TT/CT genotype; adjusted Odds Ratio: 4.28; 95%CI: 2.01, 9.10; P < 0.01). Conclusions: This study indicates that IFNL3 CC genotype predicts higher HCV RNA levels in early acute HCV infection.",
keywords = "Acute HCV, Cohort study, IFNL3 genotype, IL28B genotype, Viral load",
author = "{on behalf of the InC3Study Group} and Behzad Hajarizadeh and Bart Grady and Kimberly Page and Kim, {Arthur Y.} and McGovern, {Barbara H.} and Cox, {Andrea L.} and Rice, {Thomas M.} and Rachel Sacks-Davis and Julie Bruneau and Meghan Morris and Janaki Amin and Janke Schinkel and Tanya Applegate and Lisa Maher and Margaret Hellard and Lloyd, {Andrew R.} and Maria Prins and Geskus, {Ronald B.} and Dore, {Gregory J.} and Jason Grebely and Georg Lauer and Shoukry, {Naglaa H.} and Judy Hahn and Steve Shiboski and Rice, {T. M.} and Maryam Alavi and Rachel Bouchard and Jasneet Aneja and Suzy Teutsch and Bethany White and Brittany Wells and Geng Zang and Gail Matthews and Pip Marks and Barbara Yeung and Prince, {Leslie Erin} and Elise Roy and Anna Bates and Jarliene Enriquez and Sammy Chow and Luke McCredie and Campbell Aitken and Joseph Doyle and Tim Spelman and Jennifer Evans",
note = "Funding Information: The InC 3 Study is supported by the National Institute on Drug Abuse Award Number R01DA031056. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Drug Abuse or the National Institutes of Health. The Kirby Institute is funded by the Australian Government Department of Health and Ageing. The views expressed in this publication do not necessarily represent the position of the Australian Government. Publisher Copyright: {\textcopyright} 2014 Elsevier B.V.",
year = "2014",
month = nov,
day = "1",
doi = "10.1016/j.jcv.2014.08.027",
language = "English (US)",
volume = "61",
pages = "430--434",
journal = "Journal of Clinical Virology",
issn = "1386-6532",
publisher = "Elsevier",
number = "3",
}