TY - JOUR
T1 - Interfering with Theories of Sleep and Memory
T2 - Sleep, Declarative Memory, and Associative Interference
AU - Ellenbogen, Jeffrey M.
AU - Hulbert, Justin C.
AU - Stickgold, Robert
AU - Dinges, David F.
AU - Thompson-Schill, Sharon L.
N1 - Funding Information:
The authors thank Marina Bedny, Michael Kahana, Matthew Walker, John Orav, and Hans Van Dongen for their thoughtful insights and constructive contributions to the success of this project. We similarly appreciate the contributions of Mary Filance, Adele Haimovic, Chris Johnnidis, and Annie Yang to the implementation of this research. This work was supported by the University of Pennsylvania's Nassau Undergraduate Research Fund (J.C.H.) and by the National Institutes of Health: NIH-R01-MH067008 (S.T.S.); NIH-R01-MH048832 (R.S.); NIH-K30-HL04095 (J.M.E.); and NIH-T32-HL007901 (J.M.E.).
PY - 2006/7/11
Y1 - 2006/7/11
N2 - Mounting behavioral evidence in humans supports the claim that sleep leads to improvements in recently acquired, nondeclarative memories. Examples include motor-sequence learning [1, 2]; visual-discrimination learning [3]; and perceptual learning of a synthetic language [4]. In contrast, there are limited human data supporting a benefit of sleep for declarative (hippocampus-mediated) memory in humans (for review, see [5]). This is particularly surprising given that animal models (e.g., [6-8]) and neuroimaging studies (e.g., [9]) predict that sleep facilitates hippocampus-based memory consolidation. We hypothesized that we could unmask the benefits of sleep by challenging the declarative memory system with competing information (interference). This is the first study to demonstrate that sleep protects declarative memories from subsequent associative interference, and it has important implications for understanding the neurobiology of memory consolidation.
AB - Mounting behavioral evidence in humans supports the claim that sleep leads to improvements in recently acquired, nondeclarative memories. Examples include motor-sequence learning [1, 2]; visual-discrimination learning [3]; and perceptual learning of a synthetic language [4]. In contrast, there are limited human data supporting a benefit of sleep for declarative (hippocampus-mediated) memory in humans (for review, see [5]). This is particularly surprising given that animal models (e.g., [6-8]) and neuroimaging studies (e.g., [9]) predict that sleep facilitates hippocampus-based memory consolidation. We hypothesized that we could unmask the benefits of sleep by challenging the declarative memory system with competing information (interference). This is the first study to demonstrate that sleep protects declarative memories from subsequent associative interference, and it has important implications for understanding the neurobiology of memory consolidation.
KW - SYSNEURO
UR - http://www.scopus.com/inward/record.url?scp=33745669729&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745669729&partnerID=8YFLogxK
U2 - 10.1016/j.cub.2006.05.024
DO - 10.1016/j.cub.2006.05.024
M3 - Article
C2 - 16824917
AN - SCOPUS:33745669729
SN - 0960-9822
VL - 16
SP - 1290
EP - 1294
JO - Current Biology
JF - Current Biology
IS - 13
ER -