Interface haze associated with topical nonsteroidal anti-inflammatory drug use after descemet stripping automated Endothelial Keratoplasty

Purpose: To determine if topical nonsteroidal anti-inflammatory drug (NSAID) use after Descemet stripping automated endothelial keratoplasty (DSAEK) is associated with the development of interface haze. Methods: A retrospective case-control study of patients undergoing DSAEK surgery. Results: Of the 61 patients receiving topical NSAIDs, 51% were noted to develop interface haze, and 9% of the control group (N=100, no NSAID) developed haze. There was no significant difference in best corrected visual acuity between the 2 groups. Conclusions: Topical NSAID use is associated with the development of interface haze, although it may not be visually significant and could be related to confounding factors.