Intercellular miscommunication in polyglutamine pathogenesis

Christopher A. Ross; Don W. Cleveland

doi:10.1038/nn1006-1205

Intercellular miscommunication in polyglutamine pathogenesis

Christopher A. Ross, Don W. Cleveland

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

A new paper demonstrates that polyglutamine pathogenesis in spinocerebellar ataxia need not be cell autonomous. Mutant ataxin-7 expression restricted to Bergmann glia was sufficient to cause Purkinje cell degeneration and neuronal pathology.

Original language	English (US)
Pages (from-to)	1205-1206
Number of pages	2
Journal	Nature neuroscience
Volume	9
Issue number	10
DOIs	https://doi.org/10.1038/nn1006-1205
State	Published - Oct 2006

ASJC Scopus subject areas

Neuroscience(all)

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10.1038/nn1006-1205

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title = "Intercellular miscommunication in polyglutamine pathogenesis",

abstract = "A new paper demonstrates that polyglutamine pathogenesis in spinocerebellar ataxia need not be cell autonomous. Mutant ataxin-7 expression restricted to Bergmann glia was sufficient to cause Purkinje cell degeneration and neuronal pathology.",

author = "Ross, {Christopher A.} and Cleveland, {Don W.}",

year = "2006",

month = oct,

doi = "10.1038/nn1006-1205",

language = "English (US)",

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AU - Ross, Christopher A.

AU - Cleveland, Don W.

PY - 2006/10

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N2 - A new paper demonstrates that polyglutamine pathogenesis in spinocerebellar ataxia need not be cell autonomous. Mutant ataxin-7 expression restricted to Bergmann glia was sufficient to cause Purkinje cell degeneration and neuronal pathology.

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M3 - Short survey

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JO - Nature neuroscience

JF - Nature neuroscience

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Intercellular miscommunication in polyglutamine pathogenesis

Abstract

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