Interaction between RANTES promoter variant and CCR5Δ32 favors recovery from hepatitis B

Chloe L. Thio, Jacquie Astemborski, Rasmi Thomas, Timothy Mosbruger, Mallory D. Witt, James J. Goedert, Keith Hoots, Cherie Winkler, David L. Thomas, Mary Carrington

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Recovery from acute hepatitis B virus (HBV) infection occurs in 95% of adult-acquired infections. A 32-bp deletion in CCR5 (CCR5Δ32), which encodes for a nonfunctional receptor, increases the likelihood of recovery. Using 181 subjects with persistent HBV infection and 316 who had recovered, we tested the hypothesis that an epistatic interaction between functional polymorphisms in RANTES (a CCR5 ligand) and CCR5 impacts recovery. Specific models designed to assess individual contributions of compound genotypes demonstrated that the only combination associated with recovery from an HBV infection was RANTES -403A with CCR5Δ32 (odds ratio 0.36, p = 0.02). Because the phenotypic consequence of -403A is reported to be higher levels of RANTES, we propose a model in which excess RANTES in combination with low CCR5 favors recovery from an HBV infection, which will require validation through functional testing.

Original languageEnglish (US)
Pages (from-to)7944-7947
Number of pages4
JournalJournal of Immunology
Issue number11
StatePublished - Dec 1 2009

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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