TY - JOUR
T1 - Interaction between RANTES promoter variant and CCR5Δ32 favors recovery from hepatitis B
AU - Thio, Chloe L.
AU - Astemborski, Jacquie
AU - Thomas, Rasmi
AU - Mosbruger, Timothy
AU - Witt, Mallory D.
AU - Goedert, James J.
AU - Hoots, Keith
AU - Winkler, Cherie
AU - Thomas, David L.
AU - Carrington, Mary
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Recovery from acute hepatitis B virus (HBV) infection occurs in 95% of adult-acquired infections. A 32-bp deletion in CCR5 (CCR5Δ32), which encodes for a nonfunctional receptor, increases the likelihood of recovery. Using 181 subjects with persistent HBV infection and 316 who had recovered, we tested the hypothesis that an epistatic interaction between functional polymorphisms in RANTES (a CCR5 ligand) and CCR5 impacts recovery. Specific models designed to assess individual contributions of compound genotypes demonstrated that the only combination associated with recovery from an HBV infection was RANTES -403A with CCR5Δ32 (odds ratio 0.36, p = 0.02). Because the phenotypic consequence of -403A is reported to be higher levels of RANTES, we propose a model in which excess RANTES in combination with low CCR5 favors recovery from an HBV infection, which will require validation through functional testing.
AB - Recovery from acute hepatitis B virus (HBV) infection occurs in 95% of adult-acquired infections. A 32-bp deletion in CCR5 (CCR5Δ32), which encodes for a nonfunctional receptor, increases the likelihood of recovery. Using 181 subjects with persistent HBV infection and 316 who had recovered, we tested the hypothesis that an epistatic interaction between functional polymorphisms in RANTES (a CCR5 ligand) and CCR5 impacts recovery. Specific models designed to assess individual contributions of compound genotypes demonstrated that the only combination associated with recovery from an HBV infection was RANTES -403A with CCR5Δ32 (odds ratio 0.36, p = 0.02). Because the phenotypic consequence of -403A is reported to be higher levels of RANTES, we propose a model in which excess RANTES in combination with low CCR5 favors recovery from an HBV infection, which will require validation through functional testing.
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U2 - 10.4049/jimmunol.181.11.7944
DO - 10.4049/jimmunol.181.11.7944
M3 - Article
C2 - 19017985
AN - SCOPUS:71849115380
SN - 0022-1767
VL - 181
SP - 7944
EP - 7947
JO - Journal of Immunology
JF - Journal of Immunology
IS - 11
ER -