Intensity-modulated radiation therapy for anal cancer

Brian G. Czito, Joseph M. Pepek, Jeffrey J. Meyer, Sua Yoo, Christopher G. Willett

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


The contemporary treatment of anal cancer is combined-modality therapy with radiation therapy, fluorouracil, and mitomycin. This therapy results in long-term disease-free survival and sphincter preservation in the majority of patients. Tempering these positive results is the high rate of treatment-related morbidity associated with chemoradiation therapy for anal cancer. The use of intensity-modulated radiation therapy (IMRT) has the potential to reduce acute and chronic treatment-related toxicity, minimize treatment breaks, and potentially improve disease-related outcomes by permitting radiation dose escalation in selected cases.

Original languageEnglish (US)
Issue number12
StatePublished - Nov 15 2009
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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