Intensity fluctuation spectroscopy monitors contractile activation in "resting" cardiac muscle

Donald L. Lappé; Edward G. Lakatta

doi:10.1126/science.7355295

Intensity fluctuation spectroscopy monitors contractile activation in "resting" cardiac muscle

Donald L. Lappé, Edward G. Lakatta

Research output: Contribution to journal › Article › peer-review

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Abstract

Intensity fluctuations in a laser beam scattered by nonbeating isolated rat cardiac muscle varied directly with the calcium concentration in the bathing fluid. The steady-state level of these fluctuations varied directly with calcium-dependent force suggesting that the intensity fluctuations reflect an interaction of calcium ions with the myofilaments. The demonstration that both a portion of resting force and the frequency of intensity fluctuations vary directly with calcium even in quiescent conditions indicates that some contractile activation is present in the resting muscle.

Original language	English (US)
Pages (from-to)	1369-1371
Number of pages	3
Journal	Science
Volume	207
Issue number	4437
DOIs	https://doi.org/10.1126/science.7355295
State	Published - Jan 1 1980
Externally published	Yes

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abstract = "Intensity fluctuations in a laser beam scattered by nonbeating isolated rat cardiac muscle varied directly with the calcium concentration in the bathing fluid. The steady-state level of these fluctuations varied directly with calcium-dependent force suggesting that the intensity fluctuations reflect an interaction of calcium ions with the myofilaments. The demonstration that both a portion of resting force and the frequency of intensity fluctuations vary directly with calcium even in quiescent conditions indicates that some contractile activation is present in the resting muscle.",

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AB - Intensity fluctuations in a laser beam scattered by nonbeating isolated rat cardiac muscle varied directly with the calcium concentration in the bathing fluid. The steady-state level of these fluctuations varied directly with calcium-dependent force suggesting that the intensity fluctuations reflect an interaction of calcium ions with the myofilaments. The demonstration that both a portion of resting force and the frequency of intensity fluctuations vary directly with calcium even in quiescent conditions indicates that some contractile activation is present in the resting muscle.

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Intensity fluctuation spectroscopy monitors contractile activation in "resting" cardiac muscle

Abstract

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