TY - JOUR
T1 - Integrating canonical and metabolic signalling programmes in the regulation of T cell responses
AU - Pollizzi, Kristen N.
AU - Powell, Jonathan D.
N1 - Funding Information:
The authors thank F. Pan for critical review of this manuscript. The authors’ work is supported by the US National Institutes of Health (grant R01AI07761001A2). The authors apologize to those colleagues whose work has not been cited owing to space constraints.
PY - 2014/7
Y1 - 2014/7
N2 - Over the past decade, our understanding of T cell activation, differentiation and function has markedly expanded, providing a greater appreciation of the signals and pathways that regulate these processes. It has become clear that evolutionarily conserved pathways that regulate stress responses, metabolism, autophagy and survival have crucial and specific roles in regulating T cell responses. Recent studies suggest that the metabolic pathways involving MYC, hypoxia-inducible factor 1? (HIF1?), AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) are activated upon antigen recognition and that they are required for directing the consequences of T cell receptor engagement. The purpose of this Review is to provide an integrated view of the role of these metabolic pathways and of canonical T cell signalling pathways in regulating the outcome of T cell responses.
AB - Over the past decade, our understanding of T cell activation, differentiation and function has markedly expanded, providing a greater appreciation of the signals and pathways that regulate these processes. It has become clear that evolutionarily conserved pathways that regulate stress responses, metabolism, autophagy and survival have crucial and specific roles in regulating T cell responses. Recent studies suggest that the metabolic pathways involving MYC, hypoxia-inducible factor 1? (HIF1?), AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) are activated upon antigen recognition and that they are required for directing the consequences of T cell receptor engagement. The purpose of this Review is to provide an integrated view of the role of these metabolic pathways and of canonical T cell signalling pathways in regulating the outcome of T cell responses.
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U2 - 10.1038/nri3701
DO - 10.1038/nri3701
M3 - Review article
C2 - 24962260
AN - SCOPUS:84903277871
SN - 1474-1733
VL - 14
SP - 435
EP - 446
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 7
ER -