Integrating big data and actionable health coaching to optimize wellness

Leroy Hood, Jennifer C. Lovejoy, Nathan D. Price

Research output: Contribution to journalComment/debatepeer-review

49 Scopus citations


The Hundred Person Wellness Project (HPWP) is a 10-month pilot study of 100 'well' individuals where integrated data from whole-genome sequencing, gut microbiome, clinical laboratory tests and quantified self measures from each individual are used to provide actionable results for health coaching with the goal of optimizing wellness and minimizing disease. In a commentary in BMC Medicine, Diamandis argues that HPWP and similar projects will likely result in 'unnecessary and potential harmful over-testing'. We argue that this new approach will ultimately lead to lower costs, better healthcare, innovation and economic growth. The central points of the HPWP are: 1) it is focused on optimizing wellness through longitudinal data collection, integration and mining of individual data clouds, enabling development of predictive models of wellness and disease that will reveal actionable possibilities; and 2) by extending this study to 100,000 well people, we will establish multiparameter, quantifiable wellness metrics and identify markers for wellness to early disease transitions for most common diseases, which will ultimately allow earlier disease intervention, eventually transitioning the individual early on from a disease back to a wellness trajectory.

Original languageEnglish (US)
Article number4
JournalBMC medicine
Issue number1
StatePublished - Jan 9 2015
Externally publishedYes


  • Actionable
  • Gut microbiome
  • Health behavior change
  • P4 Medicine
  • Personalized medicine
  • Systems medicine
  • Wellness
  • Whole-genome sequencing

ASJC Scopus subject areas

  • Medicine(all)


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