@article{b091ba8ff4e24d8cbdb9eec7aa03e3cc,
title = "Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma",
abstract = "Comprehensive proteogenomic characterization in 103 treatment-naive clear cell renal cell carcinoma patient samples highlights tumor-specific alterations at the proteomic level that are unrevealed by transcriptomic profiling and proposes a revised subtyping scheme based on integrated omics analysis.",
keywords = "CPTAC, ccRCC, chromosomal translocation, drug targets, immune infiltration, phosphoproteomics, proteogenomics, proteomics, renal carcinoma, tumor microenvironment",
author = "{Clinical Proteomic Tumor Analysis Consortium} and Clark, {David J.} and Dhanasekaran, {Saravana M.} and Francesca Petralia and Jianbo Pan and Xiaoyu Song and Yingwei Hu and {da Veiga Leprevost}, Felipe and Boris Reva and Lih, {Tung Shing M.} and Chang, {Hui Yin} and Weiping Ma and Chen Huang and Ricketts, {Christopher J.} and Lijun Chen and Azra Krek and Yize Li and Dmitry Rykunov and Li, {Qing Kay} and Chen, {Lin S.} and Umut Ozbek and Suhas Vasaikar and Yige Wu and Seungyeul Yoo and Shrabanti Chowdhury and Wyczalkowski, {Matthew A.} and Jiayi Ji and Michael Schnaubelt and Andy Kong and Sunantha Sethuraman and Avtonomov, {Dmitry M.} and Minghui Ao and Antonio Colaprico and Song Cao and Cho, {Kyung Cho} and Selim Kalayci and Shiyong Ma and Wenke Liu and Kelly Ruggles and Anna Calinawan and G{\"u}m{\"u}{\c s}, {Zeynep H.} and Daniel Geizler and Emily Kawaler and Teo, {Guo Ci} and Bo Wen and Pierorazio, {Phillip M.} and Pavlovich, {Christian P.} and Jiang Qian and Zhen Zhang and Chan, {Daniel W.} and Hui Zhang",
note = "Funding Information: This work was supported by the NIH , National Cancer Institute{\textquoteright}s Clinical Proteomic Tumor Analysis Consortium (CPTAC) grants U24CA210985 , U24CA210993 , U24CA210967 , U24CA210954 , and U24CA210972 . Funding Information: This work was supported by the NIH, National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium (CPTAC) grants U24CA210985, U24CA210993, U24CA210967, U24CA210954, and U24CA210972. Conceptualization, H.R. D.C. A.I.N. P.W. and H.Z.; Methodology, D.J.C. and L.C.; Software, F.P. J.P. X.S. Y.H. F.d.V.L. B.R. T.-S.M.L. H.-Y.C. W.M. C.H. A. Krek, Y.L. D.R. L.S.C. U.O. S.V. S.Y. S. Chowdhury, J.J. A. Kong, S.S. D.M.A. N.E. Z.Z. M.C. A.I.N. and P.W.; Validation, S.M.D. K.L.Q. and K.-C.C.; Formal Analysis, D.J.C. S.M.D. F.P. J.P. X.S. Y.H. B.R. T.-S.M.L. H.-Y.C. W.M. C.H. A. Krek, Y.L. D.R. L.S.C. U.O. S.V. Y.W. S.Y. S. Chowdhury, J.J. A. Kong, S.S. D.M.A. M.A. A. Colaprico, S. Cao, S. Kalayci, S.M. W.L. K.R. D.G. E.K. G.C.T. B.W. Y.Z. S. Keegan, K.L. F.C. N.E. A.I.N. P.W. and H.Z.; Investigation, D.J.C. L.C. M.S. K.-C.C. D.W.C. and H.Z.; Resources, Q.K.L. C.P.P. G.B. A.A. J.L. and M.T.; Data Curation, D.J.C. S.M.D. W.M. M.A.W. M.S. M.A. M.C. A.I.N. P.W. and H.Z.; Writing ? Original Draft, D.J.C. A.I.N. P.W. and H.Z.; Writing ? Review & Editing, all authors; Visualization, D.J.C. S.M.D. F.P. J.P. X.S. Y.H. B.R. T.-S.M.L. C.H. C.J.R. A. Krek, Y.L. D.R. U.O. S.V. M.A. A. Calinawan, Z.H.G. Y.Z. and M.C.; Supervision, D.J.C. S.M.D. C.J.R. P.M.P. X.S.C. C.P.P. A.A.H, G.B. J.H. A.A. T.O. J.L. M.W. W.M.L. J.Q. D.F. B.Z. L.D. E.S. A.M.C. Z.Z. G.S.O. D.W.C. A.I.N. P.W. and H.Z.; Project Administration, D.J.C. C.R.K. M.T. M.M. E.S.B. M.M. T.H. A.I.R. H.R. D.W.C. A.I.N. P.W. and H.Z.; Funding Acquisition, B.Z. L.D. D.F. E.S. A.M.C. Z.Z. D.W.C. A.I.N. P.W. and H.Z. Dr. Eric Schadt serves as Chief Executive Officer for Sema4 and has an equity interest in this company. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = oct,
day = "31",
doi = "10.1016/j.cell.2019.10.007",
language = "English (US)",
volume = "179",
pages = "964--983.e31",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "4",
}