Integrated optical coherence tomography (OCT) and fluorescence laminar optical tomography (FLOT)

Yu Chen; Shuai Yuan; Jeremiah Wierwille; Renee Naphas; Qian Li; Tiffany R. Blackwell; Paul T. Winnard; Venu Raman; Kristine Glunde

doi:10.1109/JSTQE.2009.2037723

Integrated optical coherence tomography (OCT) and fluorescence laminar optical tomography (FLOT)

Yu Chen, Shuai Yuan, Jeremiah Wierwille, Renee Naphas, Qian Li, Tiffany R. Blackwell, Paul T. Winnard, Venu Raman, Kristine Glunde

School of Medicine

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Multimodal imaging represents one of the current trends in the development of biophotonics imaging technologies. This paper briefly reviews current multimodal biophotonics imaging platforms in macroscopic, microscopic, and mesoscopic (or millimeter) scales. We also present a combined optical coherence tomography and line-scan fluorescence laminar optical tomography system for co-registered structural and molecular imaging with millimeter-scale imaging depth. Experimental results using a capillary phantom filled with the fluorescence dye Cy5.5 and a human breast cancer xenograft model are presented.

Original language	English (US)
Article number	5438778
Pages (from-to)	755-766
Number of pages	12
Journal	IEEE Journal on Selected Topics in Quantum Electronics
Volume	16
Issue number	4
DOIs	https://doi.org/10.1109/JSTQE.2009.2037723
State	Published - Jul 2010

Keywords

Fluorescence laminar optical tomography (FLOT)
multimodality imaging
optical coherence tomography (OCT)

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering

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10.1109/JSTQE.2009.2037723

Cite this

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title = "Integrated optical coherence tomography (OCT) and fluorescence laminar optical tomography (FLOT)",

abstract = "Multimodal imaging represents one of the current trends in the development of biophotonics imaging technologies. This paper briefly reviews current multimodal biophotonics imaging platforms in macroscopic, microscopic, and mesoscopic (or millimeter) scales. We also present a combined optical coherence tomography and line-scan fluorescence laminar optical tomography system for co-registered structural and molecular imaging with millimeter-scale imaging depth. Experimental results using a capillary phantom filled with the fluorescence dye Cy5.5 and a human breast cancer xenograft model are presented.",

keywords = "Fluorescence laminar optical tomography (FLOT), multimodality imaging, optical coherence tomography (OCT)",

author = "Yu Chen and Shuai Yuan and Jeremiah Wierwille and Renee Naphas and Qian Li and Blackwell, {Tiffany R.} and Winnard, {Paul T.} and Venu Raman and Kristine Glunde",

note = "Funding Information: Manuscript received September 23, 2009; revised November 17, 2009; accepted November 22, 2009. Date of publication March 25, 2010; date of current version August 6, 2010. The work of Y. Chen was supported in part by the Maryland Nano-Biotechnology Award, by the Minta–Martin Award, by the University of Maryland, Baltimore–University of Maryland, College Park SEED Grant Program, and by the Prevent Cancer Foundation. The work of V. Raman was supported by the National Institute of Health under Grant P50 CA103175 (Johns Hopkins University In vivo Cellular and Molecular Imaging Centers Program). The work of K. Glunde was supported by the National Institute of Health under Grant CA134695.",

year = "2010",

month = jul,

doi = "10.1109/JSTQE.2009.2037723",

language = "English (US)",

volume = "16",

pages = "755--766",

journal = "IEEE Journal on Selected Topics in Quantum Electronics",

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T1 - Integrated optical coherence tomography (OCT) and fluorescence laminar optical tomography (FLOT)

AU - Chen, Yu

AU - Yuan, Shuai

AU - Wierwille, Jeremiah

AU - Naphas, Renee

AU - Li, Qian

AU - Blackwell, Tiffany R.

AU - Winnard, Paul T.

AU - Raman, Venu

AU - Glunde, Kristine

N1 - Funding Information: Manuscript received September 23, 2009; revised November 17, 2009; accepted November 22, 2009. Date of publication March 25, 2010; date of current version August 6, 2010. The work of Y. Chen was supported in part by the Maryland Nano-Biotechnology Award, by the Minta–Martin Award, by the University of Maryland, Baltimore–University of Maryland, College Park SEED Grant Program, and by the Prevent Cancer Foundation. The work of V. Raman was supported by the National Institute of Health under Grant P50 CA103175 (Johns Hopkins University In vivo Cellular and Molecular Imaging Centers Program). The work of K. Glunde was supported by the National Institute of Health under Grant CA134695.

PY - 2010/7

Y1 - 2010/7

N2 - Multimodal imaging represents one of the current trends in the development of biophotonics imaging technologies. This paper briefly reviews current multimodal biophotonics imaging platforms in macroscopic, microscopic, and mesoscopic (or millimeter) scales. We also present a combined optical coherence tomography and line-scan fluorescence laminar optical tomography system for co-registered structural and molecular imaging with millimeter-scale imaging depth. Experimental results using a capillary phantom filled with the fluorescence dye Cy5.5 and a human breast cancer xenograft model are presented.

AB - Multimodal imaging represents one of the current trends in the development of biophotonics imaging technologies. This paper briefly reviews current multimodal biophotonics imaging platforms in macroscopic, microscopic, and mesoscopic (or millimeter) scales. We also present a combined optical coherence tomography and line-scan fluorescence laminar optical tomography system for co-registered structural and molecular imaging with millimeter-scale imaging depth. Experimental results using a capillary phantom filled with the fluorescence dye Cy5.5 and a human breast cancer xenograft model are presented.

KW - Fluorescence laminar optical tomography (FLOT)

KW - multimodality imaging

KW - optical coherence tomography (OCT)

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Integrated optical coherence tomography (OCT) and fluorescence laminar optical tomography (FLOT)

Abstract

Keywords

ASJC Scopus subject areas

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