Integrated optical coherence tomography (OCT) and fluorescence laminar optical tomography (FLOT)

Yu Chen, Shuai Yuan, Jeremiah Wierwille, Renee Naphas, Qian Li, Tiffany R. Blackwell, Paul T. Winnard, Venu Raman, Kristine Glunde

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Multimodal imaging represents one of the current trends in the development of biophotonics imaging technologies. This paper briefly reviews current multimodal biophotonics imaging platforms in macroscopic, microscopic, and mesoscopic (or millimeter) scales. We also present a combined optical coherence tomography and line-scan fluorescence laminar optical tomography system for co-registered structural and molecular imaging with millimeter-scale imaging depth. Experimental results using a capillary phantom filled with the fluorescence dye Cy5.5 and a human breast cancer xenograft model are presented.

Original languageEnglish (US)
Article number5438778
Pages (from-to)755-766
Number of pages12
JournalIEEE Journal on Selected Topics in Quantum Electronics
Issue number4
StatePublished - Jul 2010


  • Fluorescence laminar optical tomography (FLOT)
  • multimodality imaging
  • optical coherence tomography (OCT)

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering


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