TY - JOUR
T1 - Installing oncofertility programs for breast cancer in limited versus optimum resource settings
T2 - Empirical data from 39 surveyed centers in Repro-Can-OPEN Study Part I & II
AU - Salama, Mahmoud
AU - Lambertini, M.
AU - Christianson, Ms
AU - Jayasinghe, Y.
AU - Anazodo, A.
AU - De Vos, M.
AU - Amant, F.
AU - Stern, C.
AU - Appiah, L.
AU - Woodard, T. L.
AU - Anderson, R. A.
AU - Westphal, L. M.
AU - Leach, R. E.
AU - Rodriguez-Wallberg, K. A.
AU - Patrizio, P.
AU - Woodruff, Teresa K.
N1 - Funding Information:
Collaborators of Repro-Can-OPEN Study Part I. Salama M, Ataman-Millhouse L, Braham M, Berjeb K, Khrouf M, Rodrigues JK, Reis FM, Silva TC, Sánchez F, Romero S, Smitz J, Vásquez L, Vega M, Sobral F, Terrado G, Lombardi MG, Scarella A, Bourlon MT, Verduzco-Aguirre H, Sánchez AM, Adiga SK, Tholeti P, Udupa KS, Mahajan N, Patil M, Dalvi R, Venter C, Demetriou G, Geel J, Quintana R, Rodriguez G, Quintana T, Viale L, Fraguglia M, Coirini M, Remolina-Bonilla YA, Noguera JAR, Velásquez JC, Suarez A, Arango GD, Pineda JID, Aldecoa MDC, Javed M, Al Sufyan H, Daniels N, Oranye BC, Ogunmokun AA, Onwuzurigbo KI, Okereke CJ, Whesu TC, Woodruff TK. Collaborators of Repro-Can-OPEN Study Part II. Salama M, Laronda MM, Rowell E, Erickson L, Goldman K , Smith K, Pavone M, Duncan FE, Brannigan R, Ataman-Millhouse L, Patrizio P, Rodriguez-Wallberg KA, Okutsu-Horage Y, Suzuki N, Lambertini M, Stern C, Gomez-Lobo V, Maher JY, Hsieh MH, Moravek MB, Anazodo A, Westphal LM, Anderson RA, Wallace WH, Mitchell RT, Nahata L, Whiteside S, Senapati S, Shah DK, Gracia C, Fino ME, Blakemore JK, Quinn GP, Krüssel JS, Baston-Büst DM, Liebenthron J, Andersen CY, Kristensen SG, Mamsen LS, Jayasinghe Y, Su HI, Dolmans MM, Amorim CA, Demeestere I, De Vos M, Van Moer E, Isachenko V, Isachenko E, Mallmann P, Rahimi G, Valli-Pulaski H, Steimer SR, McMahon KV, Orwig KE, Rios JS, Smith JF, Mok-Lin E, Woodruff TK.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/2
Y1 - 2022/2
N2 - Purpose: As a further step to elucidate the actual diverse spectrum of oncofertility practices for breast cancer around the globe, we present and discuss the comparisons of oncofertility practices for breast cancer in limited versus optimum resource settings based on data collected in the Repro-Can-OPEN Study Part I & II. Methods: We surveyed 39 oncofertility centers including 14 in limited resource settings from Africa, Asia & Latin America (Repro-Can-OPEN Study Part I), and 25 in optimum resource settings from the United States, Europe, Australia and Japan (Repro-Can-OPEN Study Part II). Survey questions covered the availability of fertility preservation and restoration options offered to young female patients with breast cancer as well as the degree of utilization. Results: In the Repro-Can-OPEN Study Part I & II, responses for breast cancer and calculated oncofertility scores showed the following characteristics: (1) higher oncofertility scores in optimum resource settings than in limited resource settings especially for established options, (2) frequent utilization of egg freezing, embryo freezing, ovarian tissue freezing, GnRH analogs, and fractionation of chemo- and radiotherapy, (3) promising utilization of oocyte in vitro maturation (IVM), (4) rare utilization of neoadjuvant cytoprotective pharmacotherapy, artificial ovary, and stem cells reproductive technology as they are still in preclinical or early clinical research settings, (5) recognition that technical and ethical concerns should be considered when offering advanced and innovative oncofertility options. Conclusions: We presented a plausible oncofertility best practice model to guide oncofertility teams in optimizing care for breast cancer patients in various resource settings.
AB - Purpose: As a further step to elucidate the actual diverse spectrum of oncofertility practices for breast cancer around the globe, we present and discuss the comparisons of oncofertility practices for breast cancer in limited versus optimum resource settings based on data collected in the Repro-Can-OPEN Study Part I & II. Methods: We surveyed 39 oncofertility centers including 14 in limited resource settings from Africa, Asia & Latin America (Repro-Can-OPEN Study Part I), and 25 in optimum resource settings from the United States, Europe, Australia and Japan (Repro-Can-OPEN Study Part II). Survey questions covered the availability of fertility preservation and restoration options offered to young female patients with breast cancer as well as the degree of utilization. Results: In the Repro-Can-OPEN Study Part I & II, responses for breast cancer and calculated oncofertility scores showed the following characteristics: (1) higher oncofertility scores in optimum resource settings than in limited resource settings especially for established options, (2) frequent utilization of egg freezing, embryo freezing, ovarian tissue freezing, GnRH analogs, and fractionation of chemo- and radiotherapy, (3) promising utilization of oocyte in vitro maturation (IVM), (4) rare utilization of neoadjuvant cytoprotective pharmacotherapy, artificial ovary, and stem cells reproductive technology as they are still in preclinical or early clinical research settings, (5) recognition that technical and ethical concerns should be considered when offering advanced and innovative oncofertility options. Conclusions: We presented a plausible oncofertility best practice model to guide oncofertility teams in optimizing care for breast cancer patients in various resource settings.
KW - Best practice
KW - Breast cancer
KW - Fertility preservation
KW - Limited resource settings
KW - Oncofertility
KW - Optimum resource settings
UR - http://www.scopus.com/inward/record.url?scp=85123164780&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85123164780&partnerID=8YFLogxK
U2 - 10.1007/s10815-022-02394-3
DO - 10.1007/s10815-022-02394-3
M3 - Article
C2 - 35032286
AN - SCOPUS:85123164780
SN - 1058-0468
VL - 39
SP - 505
EP - 516
JO - Journal of Assisted Reproduction and Genetics
JF - Journal of Assisted Reproduction and Genetics
IS - 2
ER -