Insight into the sialome of the bed bug, cimex lectularius

Ivo M.B. Francischetti, Eric Calvo, John F. Andersen, Van M. Pham, Amanda J. Favreau, Kent D. Barbian, Alvaro Romero, Jesus G. Valenzuela, José M.C. Ribeiro

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

The evolution of insects to a blood diet leads to the development of a saliva that antagonizes their hosts' hemostasis and inflammation. Hemostasis and inflammation are redundant processes, and thus a complex salivary potion composed of dozens or near 100 different polypeptides is commonly found by transcriptome or proteome analysis of these organisms. Several insect orders or families evolved independently to hematophagy, creating unique salivary potions in the form of novel pharmacological use of endogenous substances and in the form of unique proteins not matching other known proteins, these probably arriving by fast evolution of salivary proteins as they evade their hosts' immune response. In this work we present a preliminary description of the sialome (from the Greek Sialo = saliva) of the common bed bug Cimex lectularius, the first such work from a member of the Cimicidae family. This manuscript is a guide for the supplemental database files http://exon.niaid.nih.gov/ transcriptome/C-lectularius/S1/Cimex-S1.zip and http://exon.niaid.nih.gov/ transcriptome/C-lectularius/S2/Cimex-S2.xls

Original languageEnglish (US)
Pages (from-to)3820-3831
Number of pages12
JournalJournal of proteome research
Volume9
Issue number8
DOIs
StatePublished - Aug 6 2010
Externally publishedYes

Keywords

  • bedbug
  • saliva
  • salivary proteome
  • salivary transcriptome

ASJC Scopus subject areas

  • General Chemistry
  • Biochemistry

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