Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes

Yan Feng, Tianhua Niu, Xin Xu, Changzhong Chen, Qiongfang Li, Rongli Qian, Guoying Wang, Xiping Xu

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, and 10.4% in the control group. The DD frequency was significantly higher in the case group than in the control group (X21 = 4.77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population.

Original languageEnglish (US)
Pages (from-to)1986-1988
Number of pages3
Issue number6
StatePublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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