Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity

Adam C. Resnick; Adele M. Snowman; Bingnan M. Kang; K. Joseph Hurt; Solomon H. Snyder; Adolfo Saiardi

doi:10.1073/pnas.0506184102

Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity

Adam C. Resnick, Adele M. Snowman, Bingnan M. Kang, K. Joseph Hurt, Solomon H. Snyder, Adolfo Saiardi

School of Medicine

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

Phosphatidylinositol 3,4,5-trisphosphate is a major intracellular messenger molecule thought to be formed almost exclusively by cytosolic, wortmannin-inhiblted phosphoinositide 3-kinase family members. Inositol polyphosphate multikinase was identified as an enzyme that generates a series of water-soluble inositol phosphates. We now report the robust, physiologic, and evolutionarily conserved phosphoinositide 3-kinase activity of inositol polyphosphate multikinase, which is localized to nuclei and unaffected by wortmannin. In yeast, this inositol lipid kinase activity physiologically regulates transcription.

Original language	English (US)
Pages (from-to)	12783-12788
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	102
Issue number	36
DOIs	https://doi.org/10.1073/pnas.0506184102
State	Published - Sep 6 2005

Keywords

Lipids
Nucleus
Wortmannin

ASJC Scopus subject areas

General

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10.1073/pnas.0506184102

Cite this

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abstract = "Phosphatidylinositol 3,4,5-trisphosphate is a major intracellular messenger molecule thought to be formed almost exclusively by cytosolic, wortmannin-inhiblted phosphoinositide 3-kinase family members. Inositol polyphosphate multikinase was identified as an enzyme that generates a series of water-soluble inositol phosphates. We now report the robust, physiologic, and evolutionarily conserved phosphoinositide 3-kinase activity of inositol polyphosphate multikinase, which is localized to nuclei and unaffected by wortmannin. In yeast, this inositol lipid kinase activity physiologically regulates transcription.",

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AU - Resnick, Adam C.

AU - Snowman, Adele M.

AU - Kang, Bingnan M.

AU - Hurt, K. Joseph

AU - Snyder, Solomon H.

AU - Saiardi, Adolfo

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AB - Phosphatidylinositol 3,4,5-trisphosphate is a major intracellular messenger molecule thought to be formed almost exclusively by cytosolic, wortmannin-inhiblted phosphoinositide 3-kinase family members. Inositol polyphosphate multikinase was identified as an enzyme that generates a series of water-soluble inositol phosphates. We now report the robust, physiologic, and evolutionarily conserved phosphoinositide 3-kinase activity of inositol polyphosphate multikinase, which is localized to nuclei and unaffected by wortmannin. In yeast, this inositol lipid kinase activity physiologically regulates transcription.

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KW - Nucleus

KW - Wortmannin

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Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity

Abstract

Keywords

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