Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis

Vasiliki Koliaraki; Niki Chalkidi; Ana Henriques; Christos Tzaferis; Apostolos Polykratis; Ari Waisman; Werner Muller; David J. Hackam; Manolis Pasparakis; George Kollias

doi:10.1016/j.celrep.2018.12.072

Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis

Vasiliki Koliaraki, Niki Chalkidi, Ana Henriques, Christos Tzaferis, Apostolos Polykratis, Ari Waisman, Werner Muller, David J. Hackam, Manolis Pasparakis, George Kollias

School of Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Koliaraki et al. show that MyD88 in mesenchymal cells is responsible for its tumor-promoting role in the Apc ^min/+ model. They further show that this is a TLR4-mediated mechanism that leads to the production of pro-tumorigenic molecules, also identified in human CAFs.

Original language	English (US)
Pages (from-to)	536-545.e4
Journal	Cell Reports
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2018.12.072
State	Published - Jan 15 2019

Keywords

cancer-associated fibroblasts
innate immunity
tumor microenvironment

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2018.12.072

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title = "Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis",

abstract = " Koliaraki et al. show that MyD88 in mesenchymal cells is responsible for its tumor-promoting role in the Apc min/+ model. They further show that this is a TLR4-mediated mechanism that leads to the production of pro-tumorigenic molecules, also identified in human CAFs.",

keywords = "cancer-associated fibroblasts, innate immunity, tumor microenvironment",

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T1 - Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis

AU - Koliaraki, Vasiliki

AU - Chalkidi, Niki

AU - Henriques, Ana

AU - Tzaferis, Christos

AU - Polykratis, Apostolos

AU - Waisman, Ari

AU - Muller, Werner

AU - Hackam, David J.

AU - Pasparakis, Manolis

AU - Kollias, George

PY - 2019/1/15

Y1 - 2019/1/15

N2 - Koliaraki et al. show that MyD88 in mesenchymal cells is responsible for its tumor-promoting role in the Apc min/+ model. They further show that this is a TLR4-mediated mechanism that leads to the production of pro-tumorigenic molecules, also identified in human CAFs.

AB - Koliaraki et al. show that MyD88 in mesenchymal cells is responsible for its tumor-promoting role in the Apc min/+ model. They further show that this is a TLR4-mediated mechanism that leads to the production of pro-tumorigenic molecules, also identified in human CAFs.

KW - cancer-associated fibroblasts

KW - innate immunity

KW - tumor microenvironment

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JF - Cell Reports

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ER -

Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis

Abstract

Keywords

ASJC Scopus subject areas

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