@article{5faffe383d7a43449802c828ba54657c,
title = "Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis",
abstract = " Koliaraki et al. show that MyD88 in mesenchymal cells is responsible for its tumor-promoting role in the Apc min/+ model. They further show that this is a TLR4-mediated mechanism that leads to the production of pro-tumorigenic molecules, also identified in human CAFs.",
keywords = "cancer-associated fibroblasts, innate immunity, tumor microenvironment",
author = "Vasiliki Koliaraki and Niki Chalkidi and Ana Henriques and Christos Tzaferis and Apostolos Polykratis and Ari Waisman and Werner Muller and Hackam, {David J.} and Manolis Pasparakis and George Kollias",
note = "Funding Information: We thank Michalis Meletiou, Anna Katevaini, and Spiros Lalos for technical assistance in mouse genotyping and histology. We thank Sofia Grammenoudi for assistance in flow cytometry. We thank the Genomics Facility of BSRC “Alexander Fleming,” specifically Vaggelis Harokopos for performing RNA sequencing and Martin Reczko for initial bioinformatics analyses. We also thank the InfrafrontierGR infrastructure (co-funded by the European Regional Development Fund and Greek NSRF 2007-2013 to G.K.) for providing mouse hosting and phenotyping facilities. This work was supported by a grant from the Stavros Niarchos Foundation to the BSRC “Alexander Fleming” as part of the Foundation{\textquoteright}s initiative to support the Greek research center ecosystem and the FP7 Advanced ERC Grant MCs-inTEST (grant 340217 ) to G.K. Funding Information: We thank Michalis Meletiou, Anna Katevaini, and Spiros Lalos for technical assistance in mouse genotyping and histology. We thank Sofia Grammenoudi for assistance in flow cytometry. We thank the Genomics Facility of BSRC “Alexander Fleming,” specifically Vaggelis Harokopos for performing RNA sequencing and Martin Reczko for initial bioinformatics analyses. We also thank the InfrafrontierGR infrastructure (co-funded by the European Regional Development Fund and Greek NSRF 2007-2013 to G.K.) for providing mouse hosting and phenotyping facilities. This work was supported by a grant from the Stavros Niarchos Foundation to the BSRC “Alexander Fleming” as part of the Foundation's initiative to support the Greek research center ecosystem and the FP7 Advanced ERC Grant MCs-inTEST (grant 340217) to G.K. Publisher Copyright: {\textcopyright} 2018 The Author(s)",
year = "2019",
month = jan,
day = "15",
doi = "10.1016/j.celrep.2018.12.072",
language = "English (US)",
volume = "26",
pages = "536--545.e4",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "3",
}