Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis

Hee Sun Choi; Taejoon Won; Xuezhou Hou; Guobao Chen; William Bracamonte-Baran; Monica V. Talor; Ivana Jurčová; Ondrej Szárszoi; Lenka Čurnova; Ilja Stříž; Jody E. Hooper; Vojtěch Melenovský; Daniela Čiháková

doi:10.1016/j.celrep.2020.02.040

Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis

Hee Sun Choi, Taejoon Won, Xuezhou Hou, Guobao Chen, William Bracamonte-Baran, Monica V. Talor, Ivana Jurčová, Ondrej Szárszoi, Lenka Čurnova, Ilja Stříž, Jody E. Hooper, Vojtěch Melenovský, Daniela Čiháková

School of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Choi et al. show a pathogenic role for innate lymphoid cells (ILCs) in IL-33-induced eosinophilic pericarditis. ILCs are required for the development of pericarditis, and group 2 ILCs (ILC2s) promote the expression of eotaxin by cardiac fibroblasts. In humans, ILCs are found higher in the pericardial fluid of patients with pericarditis compared to others.

Original language	English (US)
Pages (from-to)	2989-3003.e6
Journal	Cell Reports
Volume	30
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2020.02.040
State	Published - Mar 3 2020

Keywords

IL-33
Innate lymphoid cells
cardiac inflammation
eosinophils
group 2 innate lymphoid cells
mediastinum
pericarditis
serosal cavity

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.02.040

Cite this

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title = "Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis",

abstract = "Choi et al. show a pathogenic role for innate lymphoid cells (ILCs) in IL-33-induced eosinophilic pericarditis. ILCs are required for the development of pericarditis, and group 2 ILCs (ILC2s) promote the expression of eotaxin by cardiac fibroblasts. In humans, ILCs are found higher in the pericardial fluid of patients with pericarditis compared to others.",

keywords = "IL-33, Innate lymphoid cells, cardiac inflammation, eosinophils, group 2 innate lymphoid cells, mediastinum, pericarditis, serosal cavity",

author = "Choi, {Hee Sun} and Taejoon Won and Xuezhou Hou and Guobao Chen and William Bracamonte-Baran and Talor, {Monica V.} and Ivana Jur{\v c}ov{\'a} and Ondrej Sz{\'a}rszoi and Lenka {\v C}urnova and Ilja St{\v r}{\'i}{\v z} and Hooper, {Jody E.} and Vojt{\v e}ch Melenovsk{\'y} and Daniela {\v C}ih{\'a}kov{\'a}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = mar,

day = "3",

doi = "10.1016/j.celrep.2020.02.040",

language = "English (US)",

volume = "30",

pages = "2989--3003.e6",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

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TY - JOUR

T1 - Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis

AU - Choi, Hee Sun

AU - Won, Taejoon

AU - Hou, Xuezhou

AU - Chen, Guobao

AU - Bracamonte-Baran, William

AU - Talor, Monica V.

AU - Jurčová, Ivana

AU - Szárszoi, Ondrej

AU - Čurnova, Lenka

AU - Stříž, Ilja

AU - Hooper, Jody E.

AU - Melenovský, Vojtěch

AU - Čiháková, Daniela

PY - 2020/3/3

Y1 - 2020/3/3

N2 - Choi et al. show a pathogenic role for innate lymphoid cells (ILCs) in IL-33-induced eosinophilic pericarditis. ILCs are required for the development of pericarditis, and group 2 ILCs (ILC2s) promote the expression of eotaxin by cardiac fibroblasts. In humans, ILCs are found higher in the pericardial fluid of patients with pericarditis compared to others.

AB - Choi et al. show a pathogenic role for innate lymphoid cells (ILCs) in IL-33-induced eosinophilic pericarditis. ILCs are required for the development of pericarditis, and group 2 ILCs (ILC2s) promote the expression of eotaxin by cardiac fibroblasts. In humans, ILCs are found higher in the pericardial fluid of patients with pericarditis compared to others.

KW - IL-33

KW - Innate lymphoid cells

KW - cardiac inflammation

KW - eosinophils

KW - group 2 innate lymphoid cells

KW - mediastinum

KW - pericarditis

KW - serosal cavity

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U2 - 10.1016/j.celrep.2020.02.040

DO - 10.1016/j.celrep.2020.02.040

M3 - Article

C2 - 32130902

AN - SCOPUS:85080150988

SN - 2211-1247

VL - 30

SP - 2989-3003.e6

JO - Cell Reports

JF - Cell Reports

IS - 9

ER -

Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis

Abstract

Keywords

ASJC Scopus subject areas

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