Innate immune activation: Parallels in alcohol use disorder and Alzheimer’s disease

Adriana Ramos, Radhika S. Joshi, Gyongyi Szabo

Research output: Contribution to journalReview articlepeer-review

Abstract

Alcohol use disorder is associated with systemic inflammation and organ dysfunction especially in the liver and the brain. For more than a decade, studies have highlighted alcohol abuse-mediated impairment of brain function and acceleration of neurodegeneration through inflammatory mechanisms that directly involve innate immune cells. Furthermore, recent studies indicate overlapping genetic risk factors between alcohol use and neurodegenerative disorders, specifically regarding the role of innate immunity in the pathomechanisms of both areas. Considering the pressing need for a better understanding of the relevance of alcohol abuse in dementia progression, here we summarize the molecular mechanisms of neuroinflammation observed in alcohol abuse and Alzheimer’s disease, the most common cause of dementia. In addition, we highlight mechanisms that are already established in the field of Alzheimer’s disease that may be relevant to explore in alcoholism to better understand alcohol mediated neurodegeneration and dementia, including the relevance of the liver-brain axis.

Original languageEnglish (US)
Article number910298
JournalFrontiers in Molecular Neuroscience
Volume15
DOIs
StatePublished - Sep 9 2022

Keywords

  • Alzheimer’s disease
  • alcohol
  • innate immunity
  • liver-brain axis
  • microglia
  • neuroinflammation

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Biology

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