Innate and acquired immunity intersect in a global view of the acute-phase response

Joo Yeon Yoo, Stephen Desiderio

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Recognition of stereotypic chemical patterns by sentinel cells of the innate immune system provokes a transient deviation from homeostasis, the acute-phase response (APR). Although APR effectors have been identified individually, the complexity of the response suggested that emergent properties would be uncovered by a more comprehensive examination. Our global assessment revealed that ≈7% of genes in the mouse are mobilized in the hepatic APR to endotoxin. Extensive metabolic adjustments include suppression of pathways for cholesterol, fatty acid, and phospholipid synthesis. Increased expression of genes for innate defense was accompanied by coordinate induction of the MHC class I antigen presentation machinery, illustrating an intersection between innate and adaptive immunity.

Original languageEnglish (US)
Pages (from-to)1157-1162
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number3
StatePublished - Feb 4 2003

ASJC Scopus subject areas

  • General


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