Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions

Kimberly E. Foreman; Jacques Friborg; Bala Chandran; Harutaka Katano; Tetsutaro Sata; Maria Mercader; Gary J. Nabel; Brian J. Nickoloff

doi:10.1016/S0923-1811(01)00087-1

Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions

Kimberly E. Foreman, Jacques Friborg, Bala Chandran, Harutaka Katano, Tetsutaro Sata, Maria Mercader, Gary J. Nabel, Brian J. Nickoloff

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) has been implicated in the development of Kaposi's sarcoma (KS) and several B-cell lymphoproliferative diseases. Serologic and molecular genetic association data has implicated HHV-8 as the causal agent of KS, but its role in the development of KS lesions is not understood. To examine the etiology of KS, HHV-8 was injected into normal human skin transplanted onto SCID mice. Injection of HHV-8 induced lesion formation that is morphologically and phenotypically consistent with KS, including the presence of angiogenesis and spindle-shaped cells latently infected with HHV-8. These findings suggest that HHV-8 is indeed the etiologic agent of KS, and that the virus plays an important role in initiation of this disease.

Original language	English (US)
Pages (from-to)	182-193
Number of pages	12
Journal	Journal of Dermatological Science
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/S0923-1811(01)00087-1
State	Published - Jul 2001
Externally published	Yes

Keywords

AIDS
Angiogenesis
Animal model
Kaposi's sarcoma-associated herpesvirus
Viral pathogenesis

ASJC Scopus subject areas

Dermatology

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10.1016/S0923-1811(01)00087-1

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@article{598d20a0b52e4628b74b8dbf057fda04,

title = "Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions",

abstract = "Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) has been implicated in the development of Kaposi's sarcoma (KS) and several B-cell lymphoproliferative diseases. Serologic and molecular genetic association data has implicated HHV-8 as the causal agent of KS, but its role in the development of KS lesions is not understood. To examine the etiology of KS, HHV-8 was injected into normal human skin transplanted onto SCID mice. Injection of HHV-8 induced lesion formation that is morphologically and phenotypically consistent with KS, including the presence of angiogenesis and spindle-shaped cells latently infected with HHV-8. These findings suggest that HHV-8 is indeed the etiologic agent of KS, and that the virus plays an important role in initiation of this disease.",

keywords = "AIDS, Angiogenesis, Animal model, Kaposi's sarcoma-associated herpesvirus, Viral pathogenesis",

author = "Foreman, {Kimberly E.} and Jacques Friborg and Bala Chandran and Harutaka Katano and Tetsutaro Sata and Maria Mercader and Nabel, {Gary J.} and Nickoloff, {Brian J.}",

year = "2001",

month = jul,

doi = "10.1016/S0923-1811(01)00087-1",

language = "English (US)",

volume = "26",

pages = "182--193",

journal = "Journal of Dermatological Science",

issn = "0923-1811",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions

AU - Foreman, Kimberly E.

AU - Friborg, Jacques

AU - Chandran, Bala

AU - Katano, Harutaka

AU - Sata, Tetsutaro

AU - Mercader, Maria

AU - Nabel, Gary J.

AU - Nickoloff, Brian J.

PY - 2001/7

Y1 - 2001/7

N2 - Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) has been implicated in the development of Kaposi's sarcoma (KS) and several B-cell lymphoproliferative diseases. Serologic and molecular genetic association data has implicated HHV-8 as the causal agent of KS, but its role in the development of KS lesions is not understood. To examine the etiology of KS, HHV-8 was injected into normal human skin transplanted onto SCID mice. Injection of HHV-8 induced lesion formation that is morphologically and phenotypically consistent with KS, including the presence of angiogenesis and spindle-shaped cells latently infected with HHV-8. These findings suggest that HHV-8 is indeed the etiologic agent of KS, and that the virus plays an important role in initiation of this disease.

AB - Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) has been implicated in the development of Kaposi's sarcoma (KS) and several B-cell lymphoproliferative diseases. Serologic and molecular genetic association data has implicated HHV-8 as the causal agent of KS, but its role in the development of KS lesions is not understood. To examine the etiology of KS, HHV-8 was injected into normal human skin transplanted onto SCID mice. Injection of HHV-8 induced lesion formation that is morphologically and phenotypically consistent with KS, including the presence of angiogenesis and spindle-shaped cells latently infected with HHV-8. These findings suggest that HHV-8 is indeed the etiologic agent of KS, and that the virus plays an important role in initiation of this disease.

KW - AIDS

KW - Angiogenesis

KW - Animal model

KW - Kaposi's sarcoma-associated herpesvirus

KW - Viral pathogenesis

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U2 - 10.1016/S0923-1811(01)00087-1

DO - 10.1016/S0923-1811(01)00087-1

M3 - Article

C2 - 11390203

AN - SCOPUS:0035014948

SN - 0923-1811

VL - 26

SP - 182

EP - 193

JO - Journal of Dermatological Science

JF - Journal of Dermatological Science

IS - 3

ER -

Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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