Initiation of haemoglobin synthesis by methionyl-tRNA

David Housman; Marcelo Jacobs-lorena; U. L. Rajbhandary; Harvey F. Lodish

doi:10.1038/227913a0

Initiation of haemoglobin synthesis by methionyl-tRNA

David Housman, Marcelo Jacobs-lorena, U. L. Rajbhandary, Harvey F. Lodish

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162 Scopus citations

Abstract

The synthesis of haemoglobin in a cell free system containing yeast tRNA is initiated by a specific methionine tRNA. Another methionine tRNA responds to internal codons in the messenger. The initiating methionine is removed from the nascent protein to leave valine as the terminal amino-acid, but cannot be removed when its amino group is blocked as in formylmethionine.

Original language	English (US)
Pages (from-to)	913-918
Number of pages	6
Journal	Nature
Volume	227
Issue number	5261
DOIs	https://doi.org/10.1038/227913a0
State	Published - 1970
Externally published	Yes

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title = "Initiation of haemoglobin synthesis by methionyl-tRNA",

abstract = "The synthesis of haemoglobin in a cell free system containing yeast tRNA is initiated by a specific methionine tRNA. Another methionine tRNA responds to internal codons in the messenger. The initiating methionine is removed from the nascent protein to leave valine as the terminal amino-acid, but cannot be removed when its amino group is blocked as in formylmethionine.",

author = "David Housman and Marcelo Jacobs-lorena and Rajbhandary, {U. L.} and Lodish, {Harvey F.}",

year = "1970",

doi = "10.1038/227913a0",

language = "English (US)",

volume = "227",

pages = "913--918",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "5261",

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T1 - Initiation of haemoglobin synthesis by methionyl-tRNA

AU - Housman, David

AU - Jacobs-lorena, Marcelo

AU - Rajbhandary, U. L.

AU - Lodish, Harvey F.

PY - 1970

Y1 - 1970

N2 - The synthesis of haemoglobin in a cell free system containing yeast tRNA is initiated by a specific methionine tRNA. Another methionine tRNA responds to internal codons in the messenger. The initiating methionine is removed from the nascent protein to leave valine as the terminal amino-acid, but cannot be removed when its amino group is blocked as in formylmethionine.

AB - The synthesis of haemoglobin in a cell free system containing yeast tRNA is initiated by a specific methionine tRNA. Another methionine tRNA responds to internal codons in the messenger. The initiating methionine is removed from the nascent protein to leave valine as the terminal amino-acid, but cannot be removed when its amino group is blocked as in formylmethionine.

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U2 - 10.1038/227913a0

DO - 10.1038/227913a0

M3 - Article

C2 - 4915406

AN - SCOPUS:0014967012

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SP - 913

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JO - Nature

JF - Nature

IS - 5261

ER -

Initiation of haemoglobin synthesis by methionyl-tRNA

Abstract

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