TY - GEN
T1 - Initial evaluation of a state-of-the-art commercial preclinical PET/CT scanner
AU - Lee, Taek Soo
AU - Rittenbach, Andrew
AU - Fernández, César Gutiérrez
AU - Lopez-Longas, Jesus
AU - Arco, Juan M.
AU - Tsui, Benjamin M.W.
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2017/10/16
Y1 - 2017/10/16
N2 - We performed an initial evaluation of a state-of-the-art commercial preclinical PET/CT scanner (SuperArgus 4R, SEDECAL, Madrid, Spain). The PET unit consists of 4 rings of 96 detector modules each with an array of 338 1.45 × 1.45 × 15 mm3 pixelated LYSO and GSO phoswich crystals with DOI information. It has a maximum axial FOV of 100 mm and transaxial FOV of 120 mm. The CT unit consists of an x-ray source with variable micro focal spot size and a large 229 × 145 mm2 flat-panel detector that allows imaging of a volume-of-view (VOV) at three different magnifications, at a smallest voxel of 15 micron. We measured the sensitivity and uniformity of the PET unit using a calibrated Na-22 point source and a cylindrical phantom filled with a homogeneous FDG solution. The system resolution was determined from the reconstructed images of a thin FDG-filled capillary tube in air and inside a plastic cylinder, and a hot-rod phantom using the FBP and the 3D iterative reconstruction algorithm at different iteration numbers. The uniformity of the CT unit was evaluated from a summed reconstructed image with low statistical image noise of and at three magnifications. The resolution was determined from the edge functions of images of a set of precision-machined acrylic rods of different diameters at three magnifications and with different acquired and reconstructed pixel sizes. The dual-modality image co-registration was assessed using a set of CT and PET images obtained from a phantom consisting of a Ge-68 annulus ring phantom with an attached Na-22 point source. Finally, the preclinical imaging performance of the PET/CT system were evaluated from sample images several small animal studies. Our preliminary results showed the PET unit was able to achieve a system resolution of 0.85 mm and sensitivity of ∼8.9 %, and the CT unit a highest resolution of ∼20 micron. We conclude the preclinical PET/CT system meet the stated specifications and is suitable for high performance preclinical molecular imaging of small animals.
AB - We performed an initial evaluation of a state-of-the-art commercial preclinical PET/CT scanner (SuperArgus 4R, SEDECAL, Madrid, Spain). The PET unit consists of 4 rings of 96 detector modules each with an array of 338 1.45 × 1.45 × 15 mm3 pixelated LYSO and GSO phoswich crystals with DOI information. It has a maximum axial FOV of 100 mm and transaxial FOV of 120 mm. The CT unit consists of an x-ray source with variable micro focal spot size and a large 229 × 145 mm2 flat-panel detector that allows imaging of a volume-of-view (VOV) at three different magnifications, at a smallest voxel of 15 micron. We measured the sensitivity and uniformity of the PET unit using a calibrated Na-22 point source and a cylindrical phantom filled with a homogeneous FDG solution. The system resolution was determined from the reconstructed images of a thin FDG-filled capillary tube in air and inside a plastic cylinder, and a hot-rod phantom using the FBP and the 3D iterative reconstruction algorithm at different iteration numbers. The uniformity of the CT unit was evaluated from a summed reconstructed image with low statistical image noise of and at three magnifications. The resolution was determined from the edge functions of images of a set of precision-machined acrylic rods of different diameters at three magnifications and with different acquired and reconstructed pixel sizes. The dual-modality image co-registration was assessed using a set of CT and PET images obtained from a phantom consisting of a Ge-68 annulus ring phantom with an attached Na-22 point source. Finally, the preclinical imaging performance of the PET/CT system were evaluated from sample images several small animal studies. Our preliminary results showed the PET unit was able to achieve a system resolution of 0.85 mm and sensitivity of ∼8.9 %, and the CT unit a highest resolution of ∼20 micron. We conclude the preclinical PET/CT system meet the stated specifications and is suitable for high performance preclinical molecular imaging of small animals.
KW - PET/CT
KW - Performance evaluation
KW - Small animal imaging
UR - http://www.scopus.com/inward/record.url?scp=85041498951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041498951&partnerID=8YFLogxK
U2 - 10.1109/NSSMIC.2016.8069505
DO - 10.1109/NSSMIC.2016.8069505
M3 - Conference contribution
AN - SCOPUS:85041498951
T3 - 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016
BT - 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016
Y2 - 29 October 2016 through 6 November 2016
ER -