Abstract
A computer model of the ventricular action potential was used to study the effect of trains of subthreshold high-frequency stimuli (TSc) on the prolongation of the effective refractory period (ERP). A zone of ventricular tissue is simulated by a one-dimensional structure. Trains of subthreshold high-frequency stimuli, at different frequencies were applied between the two suprathreshold pulses S1 and S2 and the ERP was measured as a function of TSc frequency. Our simulation results are in agreement with the experimental results. The results suggest that the prolongation of recovery from inactivation of the fast Na+ current could be partially responsible for the prolongation of the ERP.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 213-215 |
| Number of pages | 3 |
| Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Volume | 1 |
| State | Published - 1997 |
| Externally published | Yes |
| Event | Proceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Chicago, IL, USA Duration: Oct 30 1997 → Nov 2 1997 |
ASJC Scopus subject areas
- Signal Processing
- Biomedical Engineering
- Computer Vision and Pattern Recognition
- Health Informatics